激光光凝联合疗法治疗糖尿病视网膜病变的优势和展望  

Advantages and Prospects of Combination Therapy with Laser Photocoagulation for Diabetic Retinopathy

作　　者：庄家圆 罗向霞[2] 洪卓民 曾敏 杨芮 ZHUANG Jiayuan;LUO Xiangxia;HONG Zhuomin;ZENG Min;YANG Rui(Gansu University of Chinese Medicine,Lanzhou 730000,China)

机构地区：[1]甘肃中医药大学,兰州730000 [2]甘肃省中医院,兰州730050

出　　处：《中国中医眼科杂志》2024年第7期680-683,700,共5页China Journal of Chinese Ophthalmology

基　　金：国家自然科学基金项目(81960888);甘肃省自然科学基金优秀博士生项目(23JRRA1223);甘肃省教育厅优秀研究生“创新之星”项目(2023 CXZX-733)。

摘　　要：激光光凝是糖尿病视网膜病变的主要治疗手段,虽然激光手术方式的改良及对激光能量的控制,极大地提高了临床疗效,但研究表明视网膜激光光凝会产生视野缺损、暗适应下降等副作用。玻璃体腔注射抗血管内皮生长因子药物在一定程度上可提高患者视力,改善黄斑中心凹结构,但长期反复注射给患者带来了巨大的经济负担。近年来,眼科学者在此治疗的基础上提出激光光凝联合疗法,在降低激光副作用的同时,提高患者视功能,增强临床疗效,且具有经济效益。本文对激光光凝分别联合抗血管内皮生长因子、中药复方制剂等治疗优势及局限性进行综述,以期为制定有效的临床治疗方法提供参考。Laser photocoagulation is the primary treatment for diabetic retinopathy.Although advancements in laser surgery techniques and energy control have significantly improved clinical efficacy,some studies have shown that retinal laser photocoagulation can cause side effects such as visual field defects and decreased dark adaptation.Intravitreal injection of anti-vascular endo⁃thelial growth factor(anti-VEGF)medicines can improve patients'vision and the structure of the macular fovea to some extent,but repeated long-term injections impose a significant financial bur⁃den on patients.In recent years,ophthalmologists have proposed combination therapies with laser photocoagulation to reduce laser-induced side effects while enhancing visual function and clinical efficacy,as well as providing economic benefits.This article reviews the advantages and limita⁃tions of combining laser photocoagulation with anti-VEGF medicines and Traditional Chinese Medicine compound preparations,aiming to provide a reference for developing effective clinical treatment methods.

关 键 词：糖尿病视网膜病变 视网膜激光光凝 血管内皮生长因子 中医药 研究进展 

分 类 号：R774.1[医药卫生—眼科]