氟伏沙明联合利培酮治疗强迫症的疗效观察  

Observation on the efficacy of fluvoxamine combined with risperidone in the treatment of obsessive-compulsive disorder

作　　者：鲍晓丽 BAO Xiao-li(Fourth Department of Psychology,the Third Hospital of Dandong City,Dandong 118000,China)

机构地区：[1]丹东市第三医院心理四科,118000

出　　处：《中国现代药物应用》2024年第12期144-147,共4页Chinese Journal of Modern Drug Application

摘　　要：目的探讨氟伏沙明联合利培酮治疗强迫症的临床疗效。方法选取明确诊断强迫症的患者86例,采用随机数字表法将其分为对照组及观察组,每组43例。对照组患者单纯给予氟伏沙明治疗,观察组患者给予氟伏沙明联合利培酮治疗。比较两组治疗前以及治疗8周后的耶鲁-布朗强迫症状量表(Y-BOCS)评分及副反应量表(TESS)评分,临床疗效,不良反应发生情况。结果治疗8周后,两组Y-BOCS评分均低于本组治疗前,且观察组Y-BOCS评分(3.68±0.74)分低于对照组的(14.18±1.58)分,差异显著(P<0.05)。观察组总有效率为90.70%,显著高于对照组的74.42%,差异显著(P<0.05)。两组不良反应发生率比较,无显著差异(P>0.05)。两组患者治疗前及治疗8周后TESS评分组间比较,均无显著差异(P>0.05)。结论氟伏沙明与利培酮联合使用对强迫症的疗效更确切,显著优于利培酮单药治疗,且不会增加不良反应的发生率,值得在临床上推广应用。Objective To explore the clinical efficacy of fluvoxamine combined with risperidone in the treatment of obsessive-compulsive disorder.Methods A total of 86 patients with definite diagnosis of obsessive-compulsive disorder were selected and divided into a control group and an observation group by random number table method,with 43 cases in each group.The control group was treated with fluvoxamine alone,and the observation group was treated with fluvoxamine and risperidone.The scores of Yale-Brown Obsessive-Compulsive Scale(Y-BOCS)and Treatment Emergent Symptom Scale(TESS)before treatment and 8 weeks after treatment,clinical efficacy and occurrence of adverse reactions were compared between the two groups.Results After 8 weeks of treatment,Y-BOCS scores in both groups were lower than those before treatment;the observation group had lower Y-BOCS score of(3.68±0.74)points than(14.18±1.58)points in the control group.The difference was significant(P<0.05).The total effective rate of the observation group was 90.70%,which was significantly higher than 74.42%of the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).There was no significant difference in TESS score between the two groups before treatment and 8 weeks after treatment(P>0.05).Conclusion The combined use of fluvoxamine and risperidone is more accurate in the treatment of obsessive-compulsive disorder,which is significantly better than risperidone monotherapy,and does not increase the incidence of adverse reactions.It is worthy of clinical application.

关 键 词：精神障碍疾病 氟伏沙明 利培酮 强迫症 

分 类 号：R749.7[医药卫生—神经病学与精神病学]