外泌体非编码RNA作为结直肠癌标志物的研究进展  

Research progress on exosomal non-coding RNA as a biomarker for colorectal cancer

作　　者：张梅 杨惠雯 周瑶 蓝婷 ZHANG Mei;YANG Huiwen;ZHOU Yao;LAN Ting(School of Medical Technology,Xuzhou Medical University,Xuzhou,Jiangsu 221004,China)

机构地区：[1]徐州医科大学医学技术学院,江苏徐州221004

出　　处：《徐州医科大学学报》2024年第5期375-379,共5页Journal of Xuzhou Medical University

基　　金：国家自然科学基金(81802063);中国博士后面上项目(2022M722679)。

摘　　要：结直肠癌是目前全球常见恶性肿瘤之一,其发病率和死亡率在我国逐年升高,早期发现及治疗对改善患者的生活质量有重要意义。而结肠镜下病理活检和结直肠癌血清标志物检测无法完全实现早期诊断。外泌体是一种直径为30~140 nm的双层膜囊泡结构,具有异质性和稳定性,存在于几乎所有的体液中。研究表明,外泌体非编码RNA(miRNA、circRNA、lncRNA)与肿瘤的发生发展有着密切关系。本文对近年来外泌体非编码RNA作为结直肠癌诊断、预后及耐药的标志物相关研究作一综述。Currently,colorectal cancer is one of the common malignant tumors around the world,and its morbidity and mortality rates are increasing year by year in China.Early detection and treatment are of great important to improve patients′lives.However,colonoscopic pathological biopsy and colorectal cancer serum markers cannot fully achieve early diagnosis.Exosomes are double-membrane vesicle structures with a diameter of 30-140 nm,which are heterogeneous and stable and exist in almost all body fluids.Studies have shown that exosomal non-coding RNAs(miRNAs,circRNAs,and lncRNAs)are closely related to tumor development.In this paper,we summarize the recent research progress on exosomal non-coding RNAs as markers for the diagnosis and prognosis of colorectal cancer and drug resistance.

关 键 词：外泌体 非编码RNA 标志物 结直肠癌 诊断 预后 耐药 

分 类 号：R735[医药卫生—肿瘤]