卡波姆981添加量对槲皮素微乳凝胶流变学和体外释放特性的影响  

Influence of Carbomer 981 Concentration on the Rheological Propertyand In Vitro Release Behavior of Quercetin-loaded Microemulsion Gels

作　　者：王强 徐永林 刁岩 WANG Qiang;XU Yong-lin;DIAO Yan(Collaborative Innovation Center of Tissue Repair Material of Sichuan Province,China West Normal University,Nanchong Sichuan 637009,China;College of Life Science,China West Normal University,Nanchong Sichuan 637009,China)

机构地区：[1]西华师范大学组织修复材料工程技术协同创新中心,四川南充637009 [2]西华师范大学生命科学学院,四川南充637009

出　　处：《西华师范大学学报（自然科学版）》2024年第5期495-501,共7页Journal of China West Normal University(Natural Sciences)

基　　金：四川省自然科学基金项目(2022NSFSC1657);西华师范大学博士启动基金项目(18Q070)。

摘　　要：为了探究卡波姆981添加量对槲皮素微乳凝胶流变性质和体外释放行为的影响,将槲皮素微乳均匀分散至4种不同质量浓度的卡波姆981凝胶基质中,并比较它们的静态流变、动态流变、累积释放率的差异。结果显示:(1)含不同添加量卡波姆981的槲皮素微乳凝胶均为假塑性非牛顿流体,并可表现出更多的弹性特征;随着卡波姆981添加量的增加,槲皮素微乳凝胶的剪切应力、表观粘度、储能模量和损耗模量均依次增大。(2)槲皮素微乳凝胶体系的累积释放率与卡波姆981添加量呈负相关关系,其释放曲线符合Higuchi模型,释放机制为扩散和骨架溶蚀的结合。In this study,quercetin-loaded microemulsion is added to four different concentrations of Carbomer 981 gel matrix and the differences in static rheology,dynamic rheology and cumulative release rate of various quercetin-loaded microemulsion gels are compared for investigating the impact of Carbomer 981 concentration on the rheological property and in vitro release behavior of quercetin-loaded microemulsion gels.The results are as follows:(1)Quercetin-loaded microemulsion gels containing different concentrations of Carbomer 981 have displayed a pseudoplastic non-Newtonian fluid property and more elastic characteristics,and the shear stress,apparent viscosity,G′and G″of quercetin-loaded microemulsion gels all increased sequentially with the increase of Carbomer 981 concentration;(2)There is a negative correlation between the cumulative release rate of the quercetin-loaded microemulsion gel systems and the concentration of Carbomer 981,and the release profile follows Higuchi model with a combined releasing mechanism of diffusion and skeleton corrosion.

关 键 词：槲皮素 卡波姆981 微乳凝胶 流变性质 体外释放行为 

分 类 号：TQ658[化学工程—精细化工]