惊厥性癫痫持续状态患儿预后不良的影响因素分析  

Analysis of Factors Influencing Poor Prognosis in Children with Convulsive Status Epilepticus

作　　者：金娜 刘丹华 朱园园 王鹏飞 王媛媛 JIN Na;LIU Danhua;ZHU Yuanyuan(Kaifeng Children's Hospital,Kaifeng Henan 475000)

机构地区：[1]开封市儿童医院,河南开封475000

出　　处：《医学临床研究》2024年第6期824-826,830,共4页Journal of Clinical Research

摘　　要：【目的】探讨惊厥性癫痫持续状态(CSE)患儿预后不良的影响因素。【方法】回顾性分析2018年3月至2021年9月本院收治347例CSE患儿的临床资料,根据患儿出院时的预后情况将其分为预后良好组(n=279)和预后不良组(n=68)。比较两组一般资料及血清神经肽Y(NPY)、降钙素原(PCT)、丙氨酸氨基转移酶(ALT)、白介素-6(IL-6)、胶质纤维酸性蛋白(GFAP)、基质金属蛋白酶-9(MMP-9)、甘丙肽(GAL)水平,采用Logistic多因素回归模型分析影响CSE患儿预后不良的危险因素。【结果】347例CSE患儿预后不良发生率为19.60%(68/347)。预后不良组年龄及血清NPY、GFAP、MMP-9、GAL水平与预后良好组比较,差异有统计学意义(P<0.05)。Logistic回归分析显示,年龄<2岁、NPY>201.03 ng/L、GFAP>2.63 ng/L、MMP-9>10.69 ng/mL、GAL>67.53 ng/L是CSE患儿预后不良的危险因素(P<0.05)。【结论】CSE患儿预后不良影响因素为年龄及血清NPY、GFAP、MMP-9、GAL水平,临床医师需重点关注存在上述因素的患儿,及时给予有效的治疗。【Objective】To explore the influencing factors of poor prognosis in children with convulsive status epilepticus(CSE).【Methods】A retrospective analysis was conducted on the clinical data of 347 children with CSE admitted to our hospital from March 2018 to September 2021.Based on their prognosis at discharge,they were divided into a good prognosis group(n=279)and a poor prognosis group(n=68).Two sets of general data and serum levels of neuropeptide Y(NPY),procalcitonin(PCT),alanine aminotransferase(ALT),interleukin-6(IL-6),glial fibrillary acidic protein(GFAP),matrix metalloproteinase-9(MMP-9),and galanin(GAL)were compared.A logistic multiple regression model was used to analyze the risk factors affecting poor prognosis in children with CSE.【Results】The incidence of poor prognosis in 347 children with CSE was 19.60%(68/347).The age and serum levels of NPY,GFAP,MMP-9,and GAL in the group with poor prognosis were compared with those in the group with good prognosis,and the differences were statistically significant(P<0.05).Logistic regression analysis showed that age<2 years,NPY>201.03 ng/L,GFAP>2.63 ng/L,MMP-9>10.69 ng/mL,GAL>67.53 ng/L were risk factors for poor prognosis in children with CSE(P<0.05).【Conclusion】The adverse factors affecting the prognosis of CSE patients are age and serum levels of NPY,GFAP,MMP-9,and GAL.Clinicians should pay special attention to patients with these factors and provide timely and effective treatment measures.

关 键 词：癫痫 惊厥 预后 影响因素分析 

分 类 号：R742.1[医药卫生—神经病学与精神病学]