急性髓系白血病患者外周血miRNA-218及survivin基因表达的临床意义  

Detection and Clinical Significance of Peripheral Blood miRNA-218 and Survivin Gene Expression in Patients with Acute Myeloid Leukemia

作　　者：梁倩 刘珍珍 王晴晴 LIANG Qian;LIU Zhenzhen;WANG Qingqing(Department of Hematology,Zhoukou Central Hospital,Zhoukou Henan 466000)

机构地区：[1]周口市中心医院血液科,河南周口466000

出　　处：《医学临床研究》2024年第6期827-830,共4页Journal of Clinical Research

基　　金：周口市2023年第二批科技发展计划科技项目(项目编号:115)。

摘　　要：【目的】探讨急性髓系白血病(AML)患者外周血miRNA-218及survivin基因表达的临床意义。【方法】本院收治的86例AML患者为观察组,另选取同期在本院体检的20名健康人员为对照组,比较两组外周血中miRNA-218和survivin的相对表达量。统计观察组患者的临床资料,分析miRNA-218和survivin的水平与患者临床疗效和生存时间的关系。【结果】观察组miRNA-218水平低于对照组,survivin基因水平高于对照组(均P<0.05)。观察组中白细胞(WBC)计数≥30×10^(9)/L患者miRNA-218水平低于WBC计数<30×10^(9)/L的患者,survivin水平高于WBC计数<30×10^(9)/L的患者,且差异均有统计学意义(P<0.05)。缓解组的miRNA-218水平高于未缓解组,survivin水平低于未缓解组(均P<0.05)。miRNA-218高表达组与低表达组的中位生存时间分别为17.00个月和14.00个月,两组累积生存曲线比较,差异有统计学意义(P<0.05)。survivin高表达组与低表达组的中位生存时间分别为18.00个月和20.00个月,两组累积生存曲线比较,差异有统计学意义(P<0.05)。【结论】miRNA-218在AML患者外周血中呈低表达,survivin基因呈高表达,两者是AML患者临床疗效和预后不良的重要因素。【Objective】To investigate the detection and clinical significance of peripheral blood miRNA-218 and survivin gene expression in patients with acute myeloid leukemia(AML).【Methods】Eighty-six AML patients admitted to our hospital were selected as the observation group,and 20 healthy individuals undergoing physical examination in our hospital during the same period were selected as the control group.The relative expression levels of miRNA-218 and survivin in peripheral blood were compared between the two groups.The clinical data of the observation group were statistically analyzed to determine the relationship of the levels of miRNA-218 and survivin with the clinical efficacy and survival time of the patients.【Results】The level of miRNA-218 in the observation group was lower than that in the control group,while the level of the survivin gene was higher than that in the control group(both P<0.05).Among the observation group,patients with WBC≥30×10^(9)/L had lower level of miRNA-218 and higher level of survivin compared to patients with WBC<30×10^(9)/L,with statistically significant differences(P<0.05).The miRNA-218 level in the remission group was higher than that in the non-remission group,while the survivin level was lower in the remission group compared to the non-remission group(both P<0.05).The median survival times for the high and the low miRNA-218 expression groups were 17.00 months and 14.00 months,respectively,with statistically significant differences in the cumulative survival curves between the two groups(P<0.05).The median survival times for the high and the low survivin expression groups were 18.00 months and 20.00 months,respectively,with statistically significant differences in the cumulative survival curves between the two groups(P<0.05).【Conclusion】miRNA-218 is lowly expressed and the survivin gene is highly expressed in the peripheral blood of AML patients.Both are important factors associated with poor clinical efficacy and prognosis in AML patients.

关 键 词：白血病 髓样 急性 微RNAs/血液 基因 

分 类 号：R733.72[医药卫生—肿瘤]