精神分裂症合并医院感染患者血清T-AOC、CAT、NO、GSH-Px水平变化及临床意义  

Changes and Clinical Significance of Serum T-AOC,CAT,NO,GSH-Px Levels in Patients with Schizophrenia Complicated by Hospital Infection

作　　者：周美灵 吕传阁 王伟阁 ZHOU Meiling;LYU Chuange;WANG Weige(Shangqiu Municipal Hospital,Shangqiu Henan 476000)

机构地区：[1]商丘市立医院,河南商丘476000

出　　处：《医学临床研究》2024年第6期882-885,共4页Journal of Clinical Research

摘　　要：【目的】探讨精神分裂症(SP)合并医院感染患者血清总抗氧化能力(T-AOC)、过氧化氢酶(CAT)、一氧化氮(NO)、谷胱甘肽过氧化物酶(GSH-Px)水平变化及临床意义。【方法】选取2019年6月至2021年2月本院收治的114例SP患者(观察组),依据感染情况将患者分为感染组(n=52)和未感染组(n=62)。依据感染组患者严重程度,将患者分为轻度组(n=12)、中度组(n=25)、重度组(n=15)。同时,选取于本院同期进行体检的健康志愿者为对照组(n=71)。对比研究对象血清T-AOC、CAT、NO、GSH-Px水平,分析其与感染组病情严重程度相关性,采用受试者工作特征(ROC)曲线分析其对SP患者发生医院感染的诊断价值,采用Logistic回归方程分析SP患者发生医院感染的影响因素。【结果】观察组白细胞计数、中性粒细胞数、血小板、单核细胞数、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、NO高于对照组,淋巴细胞数、脑源性神经营养因子(BDNF)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、T-AOC、GSH-Px、CAT水平低于对照组,差异有统计学意义(P<0.05)。感染组LDL-C、NO高于未感染组,BDNF、HDL-C、CAT、T-AOC、GSH-Px水平低于对照组,差异有统计学意义(P<0.05)。血清T-AOC、CAT、GSH-Px水平比较:重度组<中度组<轻度组,差异有统计学意义(P<0.05);血清NO水平比较:重度组>中度组>轻度组,差异有统计学意义(P<0.05)。Pearson相关性分析显示,血清T-AOC、CAT、GSH-Px水平与病情严重程度呈负相关(P<0.01),血清NO水平与病情严重程度呈正相关(P<0.01)。Logistic回归方程分析显示,T-AOC<10.03 U/mL、CAT<5.34 U/mL、NO≥30.31μmol/L、GSH-Px<42.36 U/L是SP患者发生医院感染的独立危险因素(P<0.05)。ROC曲线分析显示,T-AOC、CAT、GSH-Px、NO联合检测诊断SP患者发生医院感染时曲线下面积、敏感度、特异度均优于单项检测(P<0.05)。【结论】SP发生医院感染患者血清T-AOC、CAT、GSH-Px水平降�【Objective】To explore the changes and clinical significance of serum total antioxidant capacity(T-AOC),catalase(CAT),nitric oxide(NO),and glutathione peroxidase(GSH-Px)levels in patients with schizophrenia(SP)complicated with hospital infection.【Methods】A total of 114 SP patients(observation group)admitted to our hospital from June 2019 to February 2021 were selected.According to the infection status,the patients were divided into an infected group(n=52)and an uninfected group(n=62).According to the severity of the disease,patients are divided into mild group(n=12),moderate group(n=25),and severe group(n=15).Meanwhile,healthy volunteers who underwent physical examinations at the same time in our hospital were selected as the control group(n=71).A comparative study was conducted on the serum levels of T-AOC,CAT,NO,and GSH-Px in the subjects,and their correlation with the severity of the infection group was analyzed.Receiver Operating Characteristic(ROC)curves were used to analyze their diagnostic value for the occurrence of hospital acquired infections in SP patients.Logistic regression equations were used to analyze the influencing factors of hospital acquired infections in SP.【Results】The white blood cell count,neutrophil count,platelet count,monocyte count,TC,LDL-C,and NO in the observation group were higher than those in the control group,while the lymphocyte count,BDNF,TG,HDL-C,T-AOC,CAT,and GSH-Px levels were lower than those in the control group,with statistical significance(P<0.05).The levels of LDL-C and NO in the infected group were higher than those in the uninfected group,while the levels of BDNF,HDL-C,T-AOC,CAT,and GSH-Px were lower than those in the control group,with statistical significance(P<0.05).Comparison of serum T-AOC,CAT,and GSH Px levels:the severe group<moderate group<mild group,with statistically significant differences(P<0.05);Comparison of serum NO levels:severe group>moderate group>mild group,with a statistically significant difference(P<0.05).Pearson correlation analysis s

关 键 词：精神分裂症/并发症 交叉感染/并发症 过氧化氢酶/血液 一氧化氮/血液 谷胱甘肽过氧化酶/血液 

分 类 号：R749.3[医药卫生—神经病学与精神病学]