消渴膏方治疗粤东客家人肾阴亏虚型2型糖尿病患者的疗效观察  

Clinical Observation of Xiaoke Ointment on Type 2 Diabetes Mellitus with Kidney-Yin Deficiency in Hakka People in Eastern Guangdong

作　　者：邱燕芳 赖勇辉 QIU Yan-fang;LAI Yong-hui(Meizhou People′s Hospital,Meizhou Guangdong 514100)

机构地区：[1]梅州市人民医院,广东梅州514100

出　　处：《世界中西医结合杂志》2024年第6期1168-1172,1176,共6页World Journal of Integrated Traditional and Western Medicine

基　　金：广东省中医药局计划项目(20200429205421)。

摘　　要：目的探究中医膏方消渴膏治疗粤东客家人肾阴亏虚型2型糖尿病(Type 2 diabetes mellitus,T2DM)患者的临床疗效。方法选取2021年1月—2022年12月期间梅州市人民医院收治的肾阴亏虚型T2DM患者70例作为研究对象,均为本地客家人群,根据随机数字表法分为对照组和试验组,每组各35例。对照组予常规血糖干预(胰岛素制剂治疗),试验组在对照组基础上加用口服中药膏方,疗程均为60 d。观察比较两组患者临床疗效、肾功能[尿素氮(Blood urea nitrogen,BUN)、肌酐(Serum creatinine,Scr)]、血脂[甘油三酯(Triglyceride,TC)、胆固醇(Total cholesterol,TG)]、血糖[糖化血红蛋白(Glycosylated hemoglobin,HbA1c)、空腹血糖(Fasting blood glucose,FPG)、餐后2 h血糖(2-hour Postprandial blood glucose,PBG)]及不良反应发生情况。结果治疗后试验组总有效率88.57%(31/35)明显高于对照组68.57%(24/35),差异有统计学意义(P<0.05)。治疗后两组患者中医证候积分均较治疗前降低,差异有统计学意义(P<0.05);且试验组中医证候积分明显低于对照组,差异有统计学意义(P<0.05)。治疗后两组患者BUN、Scr指标均较治疗前降低(P<0.05);且试验组BUN、Scr指标均较对照组明显降低,差异有统计学意义(P<0.05)。治疗后两组患者血脂TG、TC水平均较治疗前降低,差异有统计学意义(P<0.05);且试验组血脂TG、TC水平均明显低于对照组,差异有统计学意义(P<0.05)。治疗期间,两组患者不良反应发生情况比较,差异无统计学意义(P>0.05)。结论消渴膏方能明显改善粤东客家地区肾阴亏虚型T2DM患者的中医临床症状,降低血脂代谢紊乱,改善肾功能,从而减缓糖尿病肾病(Diabetic nephropathy,DN)及大血管病变的发生和发展。Objective To explore the clinical efficacy of the traditional Chinese medicine formula,namely Xiaoke Ointment on type 2 diabetes mellitus(T2DM)with kidney-Yin deficiency in the Hakka people in Eastern Guangdong.Methods Seventy T2DM patients with kidney-Yin deficiency,who were all local Hakka people and were admitted to Meizhou People's Hospital from January 2021 to December 2022 were selected.They were randomly divided into experimental and control groups,with 35 patients in each group.The control group was given conventional blood glucose intervention(insulin preparation treatment),and the experimental group was further given oral administration of traditional Chinese medicine formula.The course of treatment was 60 days for both groups.This paper monitored and compared the changes in clinical symptoms,renal function[blood urea nitrogen(BUN)and serum creatinine(Scr)],blood lipid[triglyceride(TC)and total cholesterol(TG)],blood glucose[glycosylated hemoglobin(HbA1c),fasting blood glucose(FPG),and 2-hour postprandial blood glucose(PBG)],and occurrence of adverse reactions of patients in the two groups.Results After treatment,the total effective rate of the experimental group was 88.57%(31/35),higher than that of the control group 68.57%(24/35),and the difference was statistically significant(P<0.05).The TCM syndrome scores in both groups were decreased after treatment(P<0.05),and the TCM syndrome scores in the experimental group were significantly lower than those in the control group(P<0.05).After treatment,the BUN and Scr in both groups decreased(P<0.05).In addition,the decrease in BUN and Scr was more obvious in the experimental group than that in the control group(P<0.05).The levels of TG and TC decreased in both groups after treatment(P<0.05),and the levels of TG and TC in the experimental groups were significantly lower than those in the control group(P<0.05).During treatment,there was no significant difference in the occurrence of adverse reactions between the two groups(P>0.05).Conclusion Xiaoke Ointment ca

关 键 词：粤东客家地区 肾阴亏虚型2型糖尿病 中药消渴膏 

分 类 号：R781.64[医药卫生—口腔医学]