千金内托散优化方治疗肛周脓肿患者术后炎症期的疗效观察  

Efficacy of Optimized Qianjin Neituosan in the Treatment of Perianal Abscess in Postoperative Inflammatory Period

作　　者：李松柱 郑雪 张侨 李春耕[1] 刘学显 李淑娟[3] LI Song-zhu;ZHENG Xue;ZHANG Qiao;LI Chun-geng;LIU Xue-xian;LI Shu-juan(Tangshan Hospital of Traditional Chinese Medicine,Tangshan Hebei 063000;Traditional Chinese Medicine College,North China University of Science and Technology,Tangshan Hebei 063000;Tianjin First Central Hospital,Tianjin 300000)

机构地区：[1]唐山市中医医院,河北唐山063000 [2]华北理工大学中医学院,河北唐山063000 [3]天津市第一中心医院,天津300000

出　　处：《世界中西医结合杂志》2024年第6期1182-1186,共5页World Journal of Integrated Traditional and Western Medicine

基　　金：河北省中医药管理局科研计划项目(2021393)。

摘　　要：目的探讨千金内托散优化方在肛周脓肿术后炎症期中的应用效果。方法选取2020年3月—2020年12月期间唐山市中医医院收治的肛周脓肿术后患者200例作为研究对象,采用随机数字表法分为对照组和治疗组,每组各100例。对照组给予康复新液+常规创面换药,治疗组给予千金内托散优化方+常规创面换药,两组均治疗7 d。观察比较两组患者临床疗效、创面愈合情况及安全性,治疗前后肛周疼痛程度评分、炎性因子[肿瘤坏死因子-α(Tumor necrosis factor-α,TNF-α)、超敏C反应蛋白(Hypersensitive C-reactive protein,hs-CRP)、激活素A(Activin A,ACTA)和白介素-1β(Interleukin-1β,IL-1β)]水平以及血管生长因子[血管内皮生长因子(Vascular endothelial growth factor,VEGF)和表皮生长因子(Epidermal growth factor,EGF)]水平。结果治疗后治疗组临床总有效率99.00%(99/100)与对照组98.00%(98/100)比较,差异无统计学意义(P>0.05);治疗组痊愈率55.00%(55/100)明显高于对照组38.00%(38/100),差异有统计学意义(P<0.05)。治疗后治疗组患者创面愈合评分、腐肉脱落、新生上皮出现以及创面愈合时间均明显低于对照组,创面面积减少率高于对照组,差异有统计学意义(P<0.05)。治疗后两组患者炎性因子TNF-α、hs-CRP、ACTA、IL-1β水平均较治疗前降低,差异有统计学意义(P<0.05);且治疗组炎性因子TNF-α、hs-CRP、ACTA、IL-1β水平均明显低于对照组,差异有统计学意义(P<0.05)。治疗后两组患者血管生长因子VEGF、EGF水平均较治疗前升高,差异有统计学意义(P<0.05);且治疗组血管生长因子VEGF、EGF水平均明显高于对照组,差异有统计学意义(P<0.05)。治疗后两组患者肛周疼痛评分均较治疗前降低,差异有统计学意义(P<0.05);且治疗组肛周疼痛评分明显低于对照组,差异有统计学意义(P<0.05)。治疗期间,两组患者均未出现明显的不良反应,具有一定的安全性。结论千金内托散�Objective To explore the application effect of the optimized Qianjin Neituosan in the treatment of perianal abscess in postoperative inflammatory period.Methods A total of 200 patients who underwent surgery for perianal abscess at Tangshan Hospital of Traditional Chinese Medicine from March 2020 to December 2020 were selected and randomly divided into a control group and a treatment group according to a random number table,with 100 cases in each group.The control group received Kangfuxin liquid and routine wound dressing change,while the treatment group received the optimized Qianjin Neituosan and routine wound dressing change,both for 7 days.The clinical efficacy,wound healing conditions,and safety of the two groups were observed and compared.The scores of perianal pain,levels of inflammatory factors[tumor necrosis factor-α(TNF-α),hypersensitive C-reactive protein(hs-CRP),activin A(ACTA),and interleukin-1β(IL-1β)],and levels of vascular growth factors[vascular endothelial growth factor(VEGF)and epidermal growth factor(EGF)]before and after treatment were also measured.Results After treatment,the total clinical effective rate was 99.00%(99/100)in the treatment group and 98%(98/100)in the control group,with no statistically significant difference(P>0.05).The cure rate in the treatment group was significantly higher at 55.00%(55/100)compared to 38.00%(38/100)in the control group(P<0.05).The scores for wound healing,eschar shedding,new epithelium appearance,and wound healing time in the treatment group were significantly lower than those in the control group,and the wound area reduction rate was higher(P<0.05).Levels of inflammatory factors TNF-α,hs-CRP,ACTA,and IL-1βin both groups were significantly reduced after treatment compared to those before treatment(P<0.05);these levels were significantly lower in the treatment group than the control group(P<0.05).Levels of vascular growth factors VEGF and EGF in both groups were significantly increased after treatment compared to those before treatment(P<0.05);these

关 键 词：千金内托散优化方 肛周脓肿 术后 炎症期 

分 类 号：R574.8[医药卫生—消化系统]