疏肝健脾法对非小细胞肺癌患者化疗期间肿瘤标志物的影响  

Effect of Shugan Jianpi method on tumor marker levels during chemotherapy in non-small cell lung cancer patients

作　　者：吴皞 薛维伟[2] 陈雪[2] 叶玲玲 李红敏[2] 孟春芹 WU Hao;XUE Weiwei;CHEN Xue;YE Lingling;LI Hongmin;MENG Chunqin(Jiangning Hospital Affiliated to Nanjing Medical University,Nanjing 211100,China)

机构地区：[1]南京医科大学附属江宁医院,江苏南京211100 [2]江苏省中医院,江苏南京210029

出　　处：《陕西中医》2024年第7期905-908,共4页Shaanxi Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金资助项目(81903968)。

摘　　要：目的:探讨疏肝健脾法对非小细胞肺癌(NSCLC)患者化疗期间肿瘤标志物水平的影响。方法:选取NSCLC患者100例,采用随机数字表法分为观察组、对照组,各50例。对照组患者给予常规化疗方案,观察组患者在对照组基础上联合疏肝健脾法。比较两组患者临床疗效,同时评估中医证候积分、血清肿瘤标志物[癌胚抗原(CEA)、癌抗原125(CA125)]、免疫功能指标[抗原分化簇4受体(CD4^(+))、抗原分化簇8受体(CD8^(+))、CD4^(+)/CD8^(+)]。最后比较两组患者不良反应发生情况。结果:观察组患者疾病控制率96.00%高于对照组84.00%,差异有统计学意义(P<0.05)。观察组患者治疗后食少纳呆、体倦乏力、神疲懒言、腹痛绵绵、舌质淡、脉细弱积分低于对照组,差异有统计学意义(均P<0.05)。观察组患者治疗后血清CEA、CA125指标低于对照组,差异有统计学意义(P<0.05)。观察组患者治疗后CD4^(+)、CD4^(+)/CD8^(+)高于对照组,CD8^(+)指标低于对照组,差异有统计学意义(均P<0.05)。观察组、对照组不良反应总发生率分别为16.00%、28.00%,组间比较差异无统计学意义(P>0.05)。结论:疏肝健脾法用于NSCLC患者化疗期间不仅能有效改善患者临床症状、体征,改善患者血清肿瘤标志物、免疫功能,安全性较理想。Objective:To explore effect of Shugan Jianpi method on tumor marker levels during chemotherapy in non-small cell lung cancer(NSCLC)patients.Methods:100 NSCLC patients were selected.They were randomly divided into observation group and control group,with 50 patients in each group,using random number table method.The control group were treated with conventional chemotherapy,while the observation group treated with combination of Shugan Jianpi methods on the basis of the control group.Compare clinical efficacy of two groups,evaluate traditional Chinese medicine syndrome scores,evaluate serum tumor markers[carcinoembryonic antigen(CEA),cancer antigen 125(CA125)]and immune function indicators[antigen differentiation cluster 4 receptor(CD4^(+)),antigen differentiation cluster 8 receptor(CD8^(+)),CD4^(+)/CD8^(+)]of the two groups.Compare incidence of adverse reactions between the two groups.Results:The disease control rate of 96.00%in the observation group was higher than that of 84.00%in the control group,difference statistically significant(P<0.05).After treatment,the observation group had significantly lower scores of food deficiency,physical fatigue and fatigue,mental fatigue and lazy speech,continuous abdominal pain,pale tongue,and weak pulse compared to the control group,with statistical significance(all P<0.05).The serum CEA and CA125 indicators of the observation group were significantly lower than those in the control group,with statistical significance(P<0.05).After treatment,the CD4^(+)and CD4^(+)/CD8^(+)indicators in the observation group were significantly higher than those in the control group,while CD8^(+)indicators ower than those in the control group,with statistical significance(all P<0.05).The total incidence of adverse reactions in the observation group and the control group was 16.00%and 28.00%,respectively with no statistically significant difference(P>0.05).Conclusion:Method of Shugan Jianpi can effectively improve clinical symptoms and signs of NSCLC patients during chemotherapy,as well as serum

关 键 词：非小细胞肺癌 疏肝健脾法 化疗 肿瘤标志物 免疫功能 中医证候积分 

分 类 号：R734.2[医药卫生—肿瘤]