超声乳化联合玻璃体注射抗VEGF药治疗白内障合并黄斑水肿的应用  

Application of phacoemulsification combined with vitreous injection of anti-VEGF drugs for cataract complicated with macular edema

作　　者：张静[1] 张大传[1] 查明轩 程红[1] Zhang Jing;Zhang Dachuan;Zha Mningxuan;Cheng Hong(Department of Ophthalmology,Hefei Third People's Hospital,Hefei 230000,China)

机构地区：[1]合肥市第三人民医院眼科,230000

出　　处：《临床眼科杂志》2024年第3期257-260,共4页Journal of Clinical Ophthalmology

摘　　要：目的观察白内障超声乳化联合玻璃体腔注射抗血管内皮生长因子(VEGF)药物治疗白内障合并各种黄斑水肿的临床效果。方法回顾性病例对照研究。选取眼科2019年1月至2022年12月期间眼科住院白内障合并各种黄斑病变(糖尿病性黄斑水肿,年龄相关性黄斑变性),高度近视脉络膜新生血管(CNV)20例(20只眼),随机分成两组,A组(10例)给予白内障超声乳化吸除联合人工晶状体植入术,术中联合玻璃体内抗VEGF药物注射,B组(10例)行白内障超声乳化联合人工晶状体植入术。随访1个月,观察两组之间治疗前后:前房及玻璃体情况、最佳矫正视力(BCVA)、黄斑中心凹厚度(CMT)、眼压的差异。结果A组术后CMT及眼压较术前降低,和B组比较差异有统计学意义(P<0.05)。两组术后BCVA都较术前提高,A组明显好于B组,差异有统计学意义(P<0.05)。结论白内障超声化术联合玻璃体抗VEGF药物,治疗白内障合并黄斑水肿应用安全有效,值得推广。Objective To observe the clinical effect of phacoemulsification combined with intravitreal antivascular endothelial growth factor(anti-VEGF)injection in treating cataract combined with various macular edema.Meth⁃ods A retrospective case-control study.20 cases of ophthalmic inpatient cataract combined with various macular diseases(diabetic macular edema,senile macular degeneration,high myopia CNV)from January 2019 to December 2022 were col⁃lected and were randomly divided into two groups.The A group(10 patients)received phacoemulsification combined with intraocular lens implantation,intraoperative intravitreal anti-VEGF drug injection.The B group(10 patients)underwent phacoemulsification combined with intraocular lens implantation.The follow-up period was 1-month,the differences in an⁃terior chamber and vitreous condition,best corrected visual acuity(BCVA),macular foveal thickness(CMT),and intra⁃ocular pressure between the two groups were observed.Results The postoperative CMT and intraocular pressure(IOP)compared with preoperative were decreased in A group,and were significantly different from B group(P<0.05).The BCVA improved in bothgroups compared with preoperative,and A group was significantly better than B group(P<0.05).Conclusions Cataract ultrasound combined with vitreous anti-VEGF drugs is safe and effective in the treatment of cata⁃ract and macular edema,and is worth popularizing.

关 键 词：超声乳化吸除术 玻璃体腔注射 抗血管内皮生长因子 白内障黄斑水肿 

分 类 号：R779.6[医药卫生—眼科]