急性脑血管疾病铜绿假单胞菌感染现状及相关疫苗研究进展  

Current status of Pseudomonas aeruginosa infection in acute cerebrovascular diseases and research progress on related vaccines

作　　者：张菁[1] 武剑[1,2,3] ZHANG Jing;WU Jian(Department of Neurology,Beijing Tsinghua Changgung Hospital,Tsinghua University,Beijing 102218,China;IDG/McGovern Institute for Brain Research at Tsinghua University;Institute for Precision Medicine,Tsinghua University,Changping District)

机构地区：[1]清华大学附属北京清华长庚医院神经内科,清华大学临床医学院,北京102218 [2]清华大学/IDG-麦戈文脑科学研究院 [3]清华大学精准医学研究院

出　　处：《中国病原生物学杂志》2024年第7期867-868,F0003,共3页Journal of Pathogen Biology

基　　金：首都卫生发展科研专项基金(No.2020-1-2241)。

摘　　要：铜绿假单胞菌是院内感染的主要病原菌,其易发展成多重耐药菌和泛耐药菌。而急性脑血管疾病患者身体虚弱,一旦感染铜绿假单胞菌将会导致治疗棘手。铜绿假单胞菌的耐药机制较复杂,包括抗生素作用靶点改变、质粒介导、生物膜形成、外排机制和膜通透性改变等。研究铜绿假单胞菌的耐药机制,有利于铜绿假单胞菌感染的治疗。铜绿假单胞菌有多种毒力因子,其中的Ⅲ型分泌系统和Ⅵ型分泌系统在铜绿假单胞菌感染中发挥着重要作用。铜绿假单胞菌的疫苗研究一直备受关注,为预防铜绿假单胞菌感染提供了新的手段。Pseudomonas aeruginosa is the main pathogen of hospital infections,which is prone to develop into multidrug-resistant and pan resistant bacteria.Patients with acute cerebrovascular disease are physically weak,and once infected with P.aeruginosa,treatment can be challenging.The drug resistance mechanism of P.aeruginosa is complex,including changes in antibiotic targets,plasmid mediated,biofilm formation,efflux mechanism,and membrane permeability changes.Studying the drug resistance mechanism of P.aeruginosa is beneficial for the treatment of P.aeruginosa infection.P.aeruginosa has multiple virulence factors,among which the Type III and Type VI secretion systems play important roles inP.aeruginosa infection.The research on vaccines against P.aeruginosa has always been of great concern,providing new means for preventing P.aeruginosa infection.

关 键 词：铜绿假单胞菌 耐药机制 分泌系统 疫苗研究 综述 

分 类 号：R743[医药卫生—神经病学与精神病学]