Evolving roles of glycosylation in the tug-of-war between virus and host  

作　　者：Xiaofeng Zhai Yanqiu Yuan Wan-Ting He Ying Wu Yi Shi Shuo Su Quansheng Du Yang Mao 

机构地区：[1]Academy for Advanced Interdisciplinary Studies,Engineering Laboratory of Animal Immunity of Jiangsu Province,College of Veterinary Medicine,Nanjing Agricultural University,China [2]State Key Laboratory of Anti-Infective Drug Discovery and Development,School of Pharmaceutical Sciences,Sun Yat-sen University,China [3]School of Pharmacy,China Pharmaceutical University,China [4]Guangdong Provincial Key Laboratory of Drug Non-Clinical Evaluation and Research,School of Pharmaceutical Sciences,Sun Yat-sen University,China [5]CAS Key Laboratory of Pathogen Microbiology and Immunology,Institute of Microbiology,Chinese Academy of Sciences,China [6]Department of Interdisciplinary Sciences,National Natural Science Foundation of China,China

出　　处：《National Science Review》2024年第5期93-97,共5页国家科学评论（英文版）

基　　金：supported by grants from the National Natural Science Foundation of China(91853131 and 81872786 to Y.M.);the National Key Research and Development Program of China(2021YFA1200903 to Y.M.,2022YFC2604203 to S.S.);the Young Elite Scientists Sponsorship Program by CAST(2023QNRC001 to W.T.H.);the Guangdong Provincial Key Laboratory of Drug Non-Clinical Evaluation and Research(2023B1212070029 to Y.M.);the Guangzhou Science and Technology Plan Project(202103000029 to Y.M.).

摘　　要：Covering the surface of both host cells and enveloped viruses,glycans are inevitable biomolecules for investigating virus–host interactions.However,due to the intricate role of glycans in the viral–host relationship,few glycanrelated molecular mechanisms have been harnessed for antiviral therapies.The intricacy arises from multiple factors.From the perspective of viral infection,host cell surface glycans are important anchoring molecules for virion binding and internalization.Fromthe perspective of host defense,innate immune cells and their associated molecules recognize viral surface glycans and mark them for destruction[1,2].Furthermore,enveloped viruses could hijack the glycosylation machinery of host cells to establish their own‘glycan shield’,enabling them to evade immune detection.Concomitantly,host cells employ glycosylation to impede the activation of envelope proteins and the assembly of virions[1,2].Glycan is such an essential weapon exploited by both viruses and hosts that a comprehensive understanding of glycan-associated mechanisms in viral infection and the immune defense of the host could facilitate the development of antiviral medicines and vaccines.In this short essay,we summarize the multifaceted function of glycans in virus–host interactions,along with challenges and future perspectives.

关 键 词：ENVELOPE arise DEFENSE 

分 类 号：R914[医药卫生—药物化学]