多巴胺奖赏系统传入调节参与抑郁机制的研究进展  

Research progress on the involvement of dopamine reward system input regulation in the mechanism of depressive disorder

作　　者：杨璐 张逸 彭劲涛 蒋宇婷 崔明湖[1] Yang Lu;Zhang Yi;Peng Jintao;Jiang Yuting;Cui Minghu(Department of Psychology,Binzhou Medical University Hospital,Binzhou 256603,China)

机构地区：[1]滨州医学院附属医院心理科,256603

出　　处：《神经疾病与精神卫生》2024年第6期441-446,共6页Journal of Neuroscience and Mental Health

摘　　要：快感缺失是抑郁症的核心症状之一,而多巴胺能系统在快感缺失中发挥关键作用。多巴胺能活动十分复杂,受多种大脑结构调节,包括海马体的腹侧下神经带、伏隔核、腹侧苍白球和基底外侧杏仁核等。基础研究和临床研究表明抑郁症中多巴胺能系统缺陷,而这些缺陷可能源于传入回路的失调。本文从抑郁症与多巴胺能系统的联系入手,总结腹侧被盖区多巴胺能神经元的上游通路,包括腹侧海马下托至伏隔核到腹侧苍白球的激活通路和基底外侧杏仁核至腹侧苍白球的抑制通路,并利用基础实验及临床研究客观阐明抑郁样行为及抑郁症中脑多巴胺能系统传入调节的异常,概述了抗抑郁治疗与中脑多巴胺能神经系统的相关性,以期为抑郁症的诊疗和机制的研究提供思路。Anhedonia is one of the core symptoms of depressive disorder,and the dopaminergic system plays a crucial role in the occurrence of anhedonia.Dopaminergic activity is highly complex and regulated by various brain structures,including the ventral subiculum,nucleus accumbens,ventral pallidum,and basolateral amygdala.Basic and clinical studies have shown that dopaminergic system defects in depressive disorder can be attributed to dysregulation of the input circuit.This paper starts with the correlation between depressive disorder and dopaminergic system,and summarizes the upstream pathways of dopaminergic neurons in the ventral tegmental area,including the activation pathway from the ventral subiculum to the nucleus accumbens to the ventral pallidum,and the inhibition pathway from the basolateral amygdala to the ventral pallidum.Moreover,this paper objectively elucidates depressive-like behavior and abnormal input regulation of the midbrain dopaminergic system in depressive disorder through basic experiments and clinical studies,and outlines the correlation between antidepressant treatment and midbrain dopaminergic nervous system,so as to provide directions for the diagnosis,treatment,and mechanism research of depressive disorder.

关 键 词：多巴胺 抑郁症 腹侧被盖区 传入调节 综述 

分 类 号：R749.4[医药卫生—神经病学与精神病学]