促红细胞生成素诱导肝细胞受体A2在胃癌作用机制和治疗中的研究进展  

Research progress of erythropoietin-producing hepatocyte receptor A2 in the mechanism and treatment of gastric cancer

作　　者：何明杰 张宇龙 常建兰[1] HE Mingjie;ZHANG Yulong;CHANG Jianlan(Department of Oncology,Heping Hospital Affiliated to Changzhi Medical College,Changzhi,Shani 046000,China)

机构地区：[1]长治医学院附属和平医院肿瘤科,山西长治046000

出　　处：《中华肿瘤防治杂志》2024年第8期500-505,共6页Chinese Journal of Cancer Prevention and Treatment

基　　金：国家自然科学基金(81800456);山西省回国留学人员科研基金(2020-131);长治医学院学术技术带头人基金(XS201902)。

摘　　要：目的对促红细胞生成素诱导肝细胞受体A2(EphA2)在胃癌疾病进程、治疗中的作用进行总结,为胃癌的治疗提供新的思路.方法以"促红细胞生成素诱导肝细胞受体A2、胃癌、血管内皮生长因子受体"为中文关键词,以"erythro-poietin-producing hepatocyte receptor A2(EphA2)、gastric cancer、epidermal growth factor receptor(VEGF)"为英文关键词,检索中国知网以及PubMed数据库2000-02-2023-08相关文献共132篇.纳入标准:(1)EphA2的基本结构、致瘤作用及调节机制;(2)EphA2在胃癌中的研究进展.排除标准:(1)内容不相关的文章;(2)相似或重复的内容.最终共纳入文献66篇.结果肿瘤中的EphA2信号转导通路复杂,大致可分为典型信号通路和非典型信号通路,EphA2在胃癌高表达,EphA2参与胃癌细胞增殖、胃癌的上皮-间质转化和胃癌血管生成过程,EphA2在促进血管生成方面与血管内皮生长因子受体具有协同作用,通常可以通过降低EphA2的表达、促进EphA2的降解,以及阻断EphA2的激活等途径来抑制EphA2的促肿瘤作用.结论EphA2在胃癌中的作用复杂,随着研究的深入,EphA2和血管内皮生长因子受体的双靶点阻断,在胃癌的治疗中可能有更大的作用.Objective To review the possible role of erythropoietin-producing hepatocyte receptor A2(EphA2)in the devel-opment and treatment of gastric cancer,and to provide new ideas for treatment of gastric cancer.Methods Relevant liter-ature was searched in China National Knowledge Infrasturcture(CNKI)and PubMed database from February,2000 to August,2023 with the keywords of"EphA2,gastric cancer,epidermal growth factor receptor(VEGF)".A total of 132 literature was retrieved.Inclusion criteria:(1)Literature on the structure,oncogenic function and regulatory mechanism of EphA2;(2)Literature on the research progress of EphA2 in gastric cancer.Exclusion criteria:(1)Articles with the above keywords but unrelated content;(2)Literature with similar or duplicate content.Finally,66 literature was includ-ed.Results EphA2 signaling pathways in tumors are complex and can be broadly divided into typical and atypical signa-ling pathways.EphA2 is highly expressed in gastric cancer,where it plays a role in angiogenesis,epithelial-mesenchymal transition,and cell proliferation of gastric cancer cells.EphA2 and VEGF have a synergistic effect on angiogenesis.The tumor-promoting effects of EphA2 can usually be inhibited by reducing EphA2 expression,promoting EphA2 degrada-tion,and blocking EphA2 activation.Conclusions EphA2 play a complex role in gastric cancer.With the deepening of re-search,EphA2 and VEGF dual target inhibition may be more effective in treating gastric cancer.

关 键 词：促红细胞生成素诱导肝细胞受体A2 EPHRINA1 胃癌 综述文献 

分 类 号：R735.2[医药卫生—肿瘤]