脂肪酸在结直肠癌发生发展中的作用及机制研究进展  

Research progress on the role and mechanism of fatty acids in colorectal cancer

作　　者：张书琳 叶兰[2] 杨光 陈佳琪 李佳轩 王洪波[1] ZHANG Shulin;YE Lan;YANG Guang;CHEN Jiaqi;LI Jiaxuan;WANG Hongbo(Second Hospital of Shandong University,Jinan,Shandong 250031,China)

机构地区：[1]山东大学第二医院消化内科,山东济南250031 [2]山东大学第二医院肿瘤防治中心,山东济南250031

出　　处：《中华肿瘤防治杂志》2024年第8期513-520,共8页Chinese Journal of Cancer Prevention and Treatment

基　　金：山东省自然科学基金(ZR2021MH104,ZR2020MH208);泰山学者工程(tsqn201909178);山东省医学会齐鲁医学专项(YXH2022ZX02112)。

摘　　要：目的分析饮食中的脂肪酸在结直肠癌发生发展过程中的作用及相关机制,以期为人们提供健康的饮食指导,达到预防及治疗结直肠癌的效果.方法以"colorectal cancer、fatty acid、lipid metabolism、inflammation、gut microbiota"为关键词,检索PubMed数据库相关文献,检索时间为2010年1月-2023年9月.纳入标准:(1)脂肪酸的分类及生物学特征;(2)脂肪酸在结直肠癌发病过程中的作用及相关机制;(3)脂肪酸在结直肠癌预防和治疗中的应用.排除标准:(1)研究机制模糊的文献;(2)会议性、评论类等文献;(3)内容相似或重复的文献.共纳入文献81篇.结果脂肪酸可通过异常的脂质代谢和炎症反应影响结直肠癌的发病进程,且与肠道微生物的相互作用也参与了此过程.其中,饱和脂肪酸与ω-6多不饱和脂肪酸可促进结直肠癌发生,而ω-3多不饱和脂肪酸对结直肠癌的发生发展有抑制作用.结论改变饮食中不同脂肪酸的摄入比例,可以有效预防结直肠癌的发生,且有望为结直肠癌的治疗提供新思路.Objective To investigate the role and associated mechanisms of dietary fatty acids in the development and onset of colorectal cancer.The goal of this study is to provide valuable dietary recommendations for promoting the colorectal cancer prevention and treatment.Methods The key words of"colorectal cancer,fatty acid,lipid metabolism,inflamma-tion,gut microbiota"were searched in PubMed database from January 2010 to September 2023.Inclusion criteria:(1)Classification and biological characteristics of fatty acids;(2)The role and associated mechanisms of fatty acids in the pathogenesis of colorectal cancer;and(3)The application of fatty acids in the prevention and treatment of colorectal canc-er.Exclusion criteria:(1)Literature with ambiguous research mechanism;(2)Conference and commentary literature;and(3)Literature with overlapping or duplicated content.A total of 81 eligible articles were included in this analysis.Re-sults Fatty acids exert their influence on the pathogenesis of colorectal cancer through disruptions in lipid metabolism and inflammatory reactions.Additionally,the interactions between fatty acids and gut microbiota are also involved in this process.Specifically,saturated fatty acids andω-6 polyunsaturated fatty acids have been found to promote colorectal canc-er,whileω-3 polyunsaturated fatty acids demonstrate inhibitory effects on colorectal cancer progression.Conclusion Modifying the dietary ratio of various fatty acids can effectively reduce the risk of colorectal cancer and may provide inno-vative approaches for the treatment of colorectal cancer.

关 键 词：结直肠癌 脂肪酸 脂质代谢 炎症 肠道微生物 综述文献 

分 类 号：R735.3[医药卫生—肿瘤]