宫颈癌患者术后复发的病理特点及5年内复发的影响因素  

Pathological characteristics of postoperative recurrence and influencing factors of recurrence within 5 years in cervical cancer patients

作　　者：陈文诗 莫羽 吴小容[1] 易妍曦 CHEN Wen-shi;MO Yu;WU Xiao-rong;YI Yan-xi(Department of Gynaecology,Central People’s Hospital of Zhanjiang,Zhanjiang 524045,China)

机构地区：[1]湛江中心人民医院妇科,广东湛江524045

出　　处：《广东医科大学学报》2024年第3期302-305,共4页Journal of Guangdong Medical University

基　　金：湛江市科技计划项目(2022A01096)。

摘　　要：目的探讨Ⅰa 2~Ⅱa 2期宫颈癌患者术后复发的病理特点及5年内复发的影响因素。方法回顾性分析2015年1月至2018年7月在湛江中心人民医院医治的375例Ⅰa 2~Ⅱa 2期宫颈癌患者的临床资料。分析Ⅰa 2~Ⅱa 2期宫颈癌患者术后复发的病理特点。根据是否5年复发将患者分为5年无复发生存(DFS)组和复发组。采用多因素logistic回归分析5年内复发的影响因素。结果375例患者5年内复发率为14.7%。5年DFS率为85.3%。在复发的病例中,Ⅱa 2期22例(40.0%)、低分化型38例(69.1%)、内生型病灶39例(70.9%)、鳞癌37例(67.3%)。Ⅱa期宫颈癌、低分化型宫颈癌、肿瘤直径≥4 cm、宫颈浸润深度>1/2肌层是5年内复发的独立危险因素。结论Ⅱa期宫颈癌、低分化型宫颈癌、肿瘤≥4 cm、宫颈浸润深度>1/2肌层的Ⅰa 2~Ⅱa 2期宫颈癌患者容易在5年内复发。Objective To investigate the pathological characteristics of postoperative recurrence and the influencing factors of recurrence within 5 years in stage Ⅰa 2-Ⅱa 2 cervical cancer patients.Methods Retrospective analysis was performed on clinical data of 375 patients with stage Ⅰa 2-Ⅱa 2 cervical cancer treated in the People’s Hospital of Zhanjiang Center from January 2015 to July 2018.The pathological characteristics of postoperative recurrence in stage Ⅰa 2-Ⅱa 2 cervical cancer patients were analyzed.Patients were divided into 5-year recurrence free survival(DFS)group and a recurrence group based on 5-year recurrence data.The influencing factors of recurrence within 5 years were determined by using multivariate logistic regression analysis.Results The 5-year DFS rate was 85.3%.Among the recurrent cases,there were 22 cases(40.0%)of stage Ⅱa 2,38 cases(69.1%)of poorly differentiated type,39 cases(70.9%)of endogenous type lesions,and 37 cases(67.3%)of squamous cell carcinoma.Stage Ⅱa cervical cancer,poorly differentiated cervical cancer,tumors≥4 cm,and cervical infiltration depth>1/2 of the myometrium were independent risk factors for recurrence within 5 years.Conclusion Patients with stage Ⅱa cervical cancer,poorly differentiated cervical cancer,tumors greater than 4 cm,and cervical infiltration depth greater than 1/2 of the myometrium in stage Ⅰa 2-Ⅱa 2 cervical cancer are prone to recurrence within 5 years.

关 键 词：Ⅰa 2~Ⅱa 2期 宫颈癌 复发 病理特点 5年无复发生存 影响因素 

分 类 号：R737.33[医药卫生—肿瘤]