血糖水平对原发性肝癌患者^(18)F-FDG PET-CT检查中正常器官摄取FDG的影响  

Impact of different blood glucose levels on FDG uptake in normal organs in ^(18)F-FDG PET-CT examination of patients with primary hepatic carcinoma

作　　者：王添艺 朱荣华 WANG Tianyi;ZHU Ronghua(Department of Imaging Medicine and Nuclear Medicine,the Third Affiliated Hospital of Naval Medical University,Shanghai 201805,China)

机构地区：[1]海军军医大学第三附属医院影像医学与核医学科,上海201805

出　　处：《中国研究型医院》2024年第3期49-53,共5页Chinese Research Hospitals

摘　　要：目的 研究在原发性肝癌患者^(18)F-FDG PET-CT检查中不同血糖水平对正常器官摄取FDG的影响,以找到相较于肝脏更为稳定的组织作为背景标准摄取值。方法 本研究为回顾性研究。搜集2022年1—6月经病理确诊为原发性肝癌,并接受^(18)F-FDG PET-CT检查的175例患者的临床及影像资料。根据注射18F-FDG前空腹血糖水平分成4组,4.0~6.3 mmol/L为血糖正常组(63例)、6.4~8.9 mmol/L为血糖稍高组(53例)、9.0~11.1 mmol/L为血糖较高组(48例)、>11.1 mmol/L为血糖极高组(11例)。比较4组患者的大脑皮质、肺脏、肝脏、脾脏、胰腺、脂肪组织及纵隔血池的最大标准摄取值(SUV_(max)),分析不同血糖水平对正常器官摄取^(18)F-FDG的影响。组间符合正态分布的计量资料比较采用方差分析、以x±s表示、两两比较采用t检验。结果 血糖稍高组、较高组和极高组的大脑皮质SUV_(max)值均明显低于血糖正常组,肝脏SUV_(max)值均明显高于血糖正常组,差异均有统计学意义(P均<0.05)。血糖稍高组的肺脏SUV_(max)值与血糖正常组比较,差异无统计学意义(P>0.05),血糖较高组与血糖极高组的肺脏SUV_(max)值均明显高于血糖正常组,差异均有统计学意义(P均<0.05)。血糖正常组、稍高组和较高组的胰腺SUV_(max)值比较,差异均无统计学意义(P均>0.05),血糖极高组明显高于血糖正常组,差异有统计学意义(P<0.05)。4组脾脏、脂肪组织及纵隔血池的SUV_(max)值差异无统计学意义(P均>0.05),表明与血糖水平无显著相关性。其中,纵隔血池SUV_(max)值最为稳定。结论 原发性肝癌患者的血糖水平,对大脑皮质、肝脏摄取^(18)F-FDG影响较大,对肺脏、胰腺的影响较小;对纵隔血池的影响最小,可作为肝脏的替代组织用于背景SUV_(max)的测量。Objective To investigate the impact of different blood glucose levels on FDG uptake in normal organs during ^(18)F-FDG PET-CT examination in patients with primary hepatic carcinoma,aiming to find tissues more stable than the liver as background standardized uptake value references.Methods This was a retrospective study.Clinical and imaging data of 175 patients diagnosed with primary hepatic carcinoma and undergoing ^(18)F-FDG PET-CT examination from January 2022 to June 2023 were collected.Patients were divided into four groups based on fasting blood glucose levels before ^(18)F-FDG injection:normal glucose group(63 cases,4.0-6.3 mmol/L),slightly elevated glucose group(53 cases,6.4-8.9 mmol/L),moderately elevated glucose group(48 cases,9.0-11.1 mmol/L),and extremely high glucose group(11 cases,>11.1 mmol/L).Maximum standardized uptake values(SUV_(max))of the cerebral cortex,lungs,liver,spleen,pancreas,adipose tissue,and mediastinal blood pool were compared among the four groups to analyze the impact of different blood glucose levels on ^(18)F-FDG uptake in normal organs.Normally distributed continuous variables were compared using analysis of variance,expressed as x±s,and pairwise comparisons were made using t-tests.Results SUV_(max) values of the cerebral cortex in the slightly elevated glucose group,moderately elevated glucose group,and extremely high glucose group were significantly lower than those in the normal glucose group,while SUV_(max) values of the liver were significantly higher than those in the normal glucose group,with all differences being statistically significant(all P<0.05).There was no statistically significant difference in SUV_(max) values of the lungs between the slightly elevated glucose group and the normal glucose group(P>0.05),but SUV_(max) values of the lungs in the moderately elevated glucose group and extremely high glucose group were significantly higher than those in the normal glucose group(all P<0.05).There was no statistically significant difference in SUV_(max) values of the p

关 键 词：血糖 ^(18)F-氟代脱氧葡萄糖 正电子发射计算机体层显像仪 最大标准摄取值 

分 类 号：R730.44[医药卫生—肿瘤] R735.7[医药卫生—临床医学]