HCN通道在听觉传导通路中的作用研究进展  

Research Progress on the Role of HCN Channels in Auditory Pathway

作　　者：葛鑫颖 周沫[1] 刘锦峰[1] 戴金升 原晶晶 刘梦婷 张娟[1] 王宁宇[1] Ge Xinying;Zhou Mo;Liu Jinfeng;Dai Jinsheng;Yuan Jingjing;Liu Mengting;Zhang Juan;Wang Ningyu(Department of Otorhinolaryngology Head and Neck Surgery,Beijing Chaoyang Hospital,Capital Medical University,Beijing,100020,China)

机构地区：[1]首都医科大学附属北京朝阳医院耳鼻咽喉头颈外科,北京100020 [2]北京中医药大学东直门医院耳鼻咽喉科

出　　处：《听力学及言语疾病杂志》2024年第4期364-368,共5页Journal of Audiology and Speech Pathology

基　　金：国家重点研发计划(2020YFC2005202);国家自然科学基金(81900934);国家自然科学基金(81770993);首发专项重点项目(2020-1-2032)。

摘　　要：超极化激活环核苷酸门控阳离子通(hyperpolarization-activated cyclic nucleotide-gated channel,HCN channel)广泛表达于中枢和周围神经系统,通过其介导的超极化激活阳离子电流(hyperpolarization-activated cation current,Ih)调节神经元的静息膜电位和兴奋性来影响听觉的精确加工和传导,对时间信息的精确分析起着至关重要的作用。因此,本文通过对HCN通道结构和分布以及电生理作用进行综述,进一步探讨HCN通道在正常及单侧聋或双侧聋情况下听觉传导通路中的作用及机制。Hyperpolarization-activated cyclic nucleotide-gated(HCN)channels are widely expressed in the central and peripheral nervous systems.They can generate hyperpolarization-activated current(Ih)that regulates the resting membrane potential and excitability of neurons.Furthermore,it can affect the precise processing and conduction of hearing,which plays a crucial role in the accurate analysis of temporal information.Therefore,through the review of HCN channel structure and distribution,as well as electrophysiological effects,the role and mechanism of HCN channels in the auditory pathways of the normal and unilateral or bilateral deafness patients will be further investigated.

关 键 词：HCN通道 超极化激活阳离子电流 听觉传导 单侧听觉剥夺 声源定位 

分 类 号：R339.16[医药卫生—人体生理学]