多指标综合评分法优选参术调脾颗粒方中白术和陈皮的醇提取工艺  

Optimization of Alcohol Extraction Process of Baizhu and Chenpi in Shenzhu Spleen-adjusting Granules by Multi-index Comprehensive Scoring Method

作　　者：刘猛 高家荣[2] 魏良兵[2] LIU Meng;GAO Jiarong;WEI Liangbing(Affiliated Hospital of West Anhui Health Vocational College,Lu′an 237008,China;The First Affiliated Hospital of Anhui University of Chinese Medicine,Hefei 230031,China)

机构地区：[1]皖西卫生职业学院附属医院,安徽六安237008 [2]安徽中医药大学第一附属医院,安徽合肥230031

出　　处：《西部中医药》2024年第7期5-9,共5页Western Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金(81603574)。

摘　　要：目的:优选参术调脾颗粒方中白术和陈皮的最佳醇提取工艺。方法:以参术调脾颗粒中醇溶性浸出物、白术内酯Ⅰ和白术内酯Ⅲ的含量为醇提取工艺的考察指标,通过多指标综合评分法考察不同因素和水平对提取工艺的影响。结果:参术调脾颗粒方中白术和陈皮最佳醇提取工艺为A1B3C2D3,即乙醇浓度65%,加10倍量乙醇,每次提取1.5 h,提取3次。结论:优选的参术调脾颗粒方中白术和陈皮醇提取工艺合理可行,有效成分提取效率高。Objective:To optimize the best alcohol extraction process of Baizhu(Atractylodis macroce-phalae rhizoma) and Chenpi(Citri reticulatae pericarpium) in Shenzhu spleen-adjusting granules.Methods:The contents of alcohol soluble extract,atractylolide Ⅰ and atractylolide Ⅲ in Shenzhu spleen-adjusting granules were used as the indexes of alcohol extraction process,and the influences of different factors and their levels on extraction process were investigated using multi-index comprehensive scoring method.Results:The best alcohol extraction process of Baizhu and Chenpi from the granules was A1B3C2D3,that is,ethanol concentrations 65%,adding ten times amount of ethanol,extracting for 1.5 h each time,three times.Conclusion:The optimized alcohol extraction process of Baizhu and Chenpi from Shenzhu spleen-adjusting granules is rational and feasible with high extraction efficiency of active ingredients.

关 键 词：参术调脾颗粒 提取工艺 白术内酯Ⅰ 白术内酯Ⅲ 多指标综合评分法 

分 类 号：R283[医药卫生—中药学]