美金刚联合多奈哌齐治疗阿尔茨海默病患者的效果  

Effects of Memantine combined with Donepezil in treatment of patients with Alzheimer's disease

作　　者：李颖[1] 李慧 李海平[3] 李薇 LI Ying;LI Hui;LI Haiping;LI Wei(Department of Pharmacy of the Affiliated Hospital of Beihua University,Jilin 132012 Jilin,China;5^(th) Department of Internal Medicine of Fusong County Hospital of Traditional Chinese Medicine,Baishan 134500 Jilin,China;Stroke ward of the Affiliated Hospital of Beihua University,Jilin 132012 Jilin,China;Pharmaceutical Department of Jilin City People’s Hospital,Jilin 132001 Jilin,China)

机构地区：[1]北华大学附属医院药学部,吉林吉林132012 [2]抚松县中医院内五科,吉林白山134500 [3]北华大学附属医院卒中病房,吉林吉林132012 [4]吉林市人民医院药学部,吉林吉林132001

出　　处：《中国民康医学》2024年第13期37-40,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:观察美金刚联合多奈哌齐治疗阿尔茨海默病(AD)患者的效果。方法:选取2020年4月至2023年4月北华大学附属医院收治的82例AD患者进行前瞻性研究,按照随机数字表法将其分为对照组和观察组各41例。对照组予以多奈哌齐治疗,观察组在对照组基础上联合美金刚治疗,两组均治疗8周。比较两组临床疗效,治疗前后认知功能[简易精神状态检查量表(MMSE)、阿尔茨海默病评定量表-认知部分(ADAS-cog)]评分、日常生活活动能力[日常生活活动能力量表(ADL)]评分、神经递质指标[5-羟色胺(5-HT)、多巴胺(DA)、乙酰胆碱(Ach)]水平,以及不良反应发生率。结果:观察组治疗总有效率为95.12%(39/41),高于对照组的78.05%(32/41),差异有统计学意义(P<0.05);治疗后,观察组MMSE、ADL评分高于对照组,ADAS-cog评分低于对照组,差异均有统计学意义(P<0.05);治疗后,观察组5-HT、DA、Ach水平均高于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:美金刚联合多奈哌齐治疗AD患者可提高治疗总有效率、日常生活活动能力评分和神经递质指标水平,改善认知功能评分,效果优于单纯多奈哌齐治疗。Objective:To observe effects of Memantine combined with Donepezil in treatment of patients with Alzheimer's disease(AD).Methods:A prospective study was conducted on 82 patients with AD admitted to the affiliated hospital of Beihua university from April 2020 to April 2023.According to the random number table method,they were divided into control group and observation group,41 cases in each group.The control group was treated with Donepezil,while the observation group was treated with Memantine on the basis of that of the control group.Both groups were treated for 8 weeks.The clinical efficacy,the scores of cognitive function [mini-mental state examination(MMSE),the Alzheimer's disease assessment scale-cognitive section(ADAS-cog)] and the activities of daily living [activities of daily living(ADL)],the neurotransmitter indexes [5-hydroxytryptamine(5-HT),dopamine(DA),acetylcholine(Ach)] levels,and incidence of adverse reactions were compared between the two groups before and after the treatment.Results:The total effective rate of the observation group was 95.12%(39/41),which was higher than 78.05%(32/41)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the MMSE and ADL scores of the observation group were higher than those of the control group,the ADAS-cog score was lower than that of the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of 5-HT,DA and Ach in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Memantine combined with Donepezil in the treatment of the AD patients can improve the total effective rate,the activities of daily living scores and the neurotransmitter index levels,and improve the cognitive function scores.Moreover,it is superior to single Donepezil treatment.

关 键 词：阿尔茨海默病 美金刚 多奈哌齐 认知功能 日常生活活动能力 神经递质 不良反应 

分 类 号：R749[医药卫生—神经病学与精神病学]