海藻酸钠口腔用水凝胶治疗牙周炎老年吸烟患者的短期疗效观察  

Short-term effect of sodium alginate oral water gel on periodontal status in elderly patients with smoking periodontitis

作　　者：倪秀凤 沈晶晶 朱燕华[1] 张人柯 Ni Xiufeng;Shen Jingjing;Zhu Yanhua;Zhang Renke(Department of Stomatology,Hangzhou Xiaoshan Hospital of Traditional Chinese Medicine Hangzhou,Zhejiang 311200,China;Department of Stomatology,Ninghai County First Hospital,Ningbo,Zhejiang 315600,China)

机构地区：[1]杭州市萧山区中医院口腔科,浙江杭州311200 [2]宁海县第一医院口腔科,浙江宁波315600

出　　处：《中国药物与临床》2024年第9期584-589,共6页Chinese Remedies & Clinics

摘　　要：目的探析海藻酸钠口腔用水凝胶对老年吸烟牙周炎患者牙周状况及龈沟液可溶性细胞间黏附分子-1(sICAM-1)、白细胞介素(IL)-1β水平的短期疗效。方法选取杭州市萧山区中医院2020年8月至2022年10月收治的152例老年吸烟牙周炎患者作为研究对象,根据治疗方法分为2组,对照组76例,在龈下刮治后应用碘甘油,观察组76例,在龈下刮治后应用海藻酸钠口腔用水凝胶。测量并统计分析2组治疗前后牙周指标[牙龈指数(GI)、龈沟出血指数(SBI)、牙菌斑指数(PLI)、牙周袋深度(PD)及附着丧失(AL)]和龈沟液sICAM-1、IL-1β、IL-6、肿瘤坏死因子(TNF)-α、不良反应发生率及短期复发率。结果2组治疗后GI、SBI、PLI、PD及AL均减小(P<0.001),观察组治疗后GI、SBI、PLI、PD及AL小于对照组,差异有统计意义(t=10.450、6.295、7.372、14.454、7.280,P<0.001);2组治疗后龈沟液sICAM-1、IL-1β、IL-6及TNF-α水平均降低(P<0.001),观察组治疗后龈沟液sICAM-1、IL-1β、IL-6及TNF-α水平低于对照组,相比差异有统计意义(t=8.993、9.684、10.184、5.664,P<0.001)。2组患者的不良反应发生率比较,差异无统计学意义(P>0.05)。随访3个月,失访率为3.3%,观察组的复发率为低于对照组的复发率(1.3%与9.6%),2组对比差异存统计学意义(χ^(2)=4.846,P=0.028)。结论海藻酸钠口腔用水凝胶能够有效改善老年吸烟牙周炎患者牙周状况,抑制牙周袋深处炎症反应,减少短期复发率,值得临床予以推广应用。Objective To investigate the short-term effect of sodium alginate oral water gel on periodontal status and levels of soluble intercellular adhesion molecule 1(sICAM-1)and interleukin-1β(IL-1β)in gingival crevicular fluid in elderly patients with smoking periodontitis.Methods A total of 152 elderly patients with smoking periodontitis admitted to Hangzhou Xiaoshan Hospital of Traditional Chinese Medicine from August 2020 to October 2022 were selected as the study subjects.According to different treatment methods,they were divided into two groups:control group(76 cases)was treated with iodine glycerin after subgingival curettage,and observation group(76 cases)was treated with sodium alginate oral water gel after subgingival curettage.Periodontal indexes[gingival index(GI),gingival sulcus bleeding index(SBI),plaque index(PLI),periodontal pocket depth(PD)and attachment loss(AL)],gingival sulcus fluid sICAM-1,IL-1β,IL-6,TNF-α,the incidence of adverse reactions and short-term recurrence rate before and after treatment were measured and statistically analyzed.Results GI,SBI,PLI,PD and AL of the two groups were decreased significantly after treatment(P<0.001).GI,SBI,PLI,PD and AL of the observation group were significantly lower than those of the control group,and the difference was statistically significant(t=10.450,6.295,7.372,14.454,7.280,P<0.01);After treatment,the levels of sICAM-1,IL-1β,IL-6 and TNF-αin gingival crevicular fluid of 2 groups were significantly decreased(P<0.01).The levels of sICAM-1,IL-1β,IL-6 and TNF-αin gingival crevicular fluid of the observation group were significantly lower than those of the control group,and the difference was statistically significant(t=8.993,9.684,10.184,5.664,P<0.01).There was no significant difference in the incidence of adverse reactions between 2 groups(P>0.05).After 3 months of follow-up,the loss of follow-up rate was 3.3%,and the recurrence rate in the observation group was significantly lower than that in the control group(1.3%vs 9.6%),and the difference betwe

关 键 词：老年人 吸烟 牙周炎 海藻酸钠口腔用水凝胶 牙周指标 复发 

分 类 号：R781.42[医药卫生—口腔医学]