阿替普酶静脉溶栓治疗急性脑梗死的效果分析  

Analysis on Effect of Intravenous Thrombolysis with Alteplase in Treatment of Acute Cerebral Infarction

作　　者：李延可 王科英 Li Yanke;Wang Keying(Binzhou Central Hospital,Binzhou 251700,Shandong Province,China)

机构地区：[1]滨州市中心医院,山东滨州251700

出　　处：《中国社区医师》2024年第15期14-16,共3页Chinese Community Doctors

摘　　要：目的:分析阿替普酶静脉溶栓治疗急性脑梗死的效果。方法:选取2021年1—12月滨州市中心医院收治的急性脑梗死患者80例作为研究对象,采用随机数字法分为观察组与对照组,各40例。对照组予以阿司匹林治疗,观察组予以阿替普酶治疗。比较两组治疗效果。结果:治疗后,两组凝血酶原时间长于治疗前,且观察组长于对照组,差异有统计学意义(P<0.05);两组凝血酶时间、活化部分凝血活酶时间短于治疗前,且观察组短于对照组,两组纤维蛋白原、凝血因子Ⅷ水平低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。治疗后,两组神经功能受损评分及神经元特异性烯醇化酶、中枢神经特异性蛋白水平低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。观察组预后良好率高于对照组,差异有统计学意义(P=0.011)。结论:阿替普酶静脉溶栓治疗急性脑梗死的效果显著,能够有效改善凝血功能,缓解神经功能损伤,改善患者预后。Objective:To analyze the effect of intravenous thrombolysis with alteplase in the treatment of acute cerebral infarction.Methods:A total of 80 patients with acute cerebral infarction admitted to Binzhou Central Hospital from January 2021 to December 2021 were selected as the study subjects.They were divided into observation group and control group according to random number table method,with 40 cases in each group.The control group was treated with aspirin,and the observation group was treated with alteplase.The treatment effects were compared between the two groups.Results:After treatment,the prothrombin time in the two groups was longer than that before treatment,and the time in the observation group was longer than that in the control group,with a statistically significant difference(P<0.05).The thrombin time and activated partial thromboplastin time in the two groups were shorter than those before treatment,and the time in the observation group were shorter than those in the control group,while the levels of fibrinogen and coagulation factorⅧin the two groups were lower than those before treatment,and the levels in the observation group were lower than those in the control group,and the difference was statistically significant(P<0.05).After treatment,the scores of impaired neurological function and the levels of neuron-specific enolase and central nervous system-specific protein in the two groups were lower than those before treatment,and the scores and levels in the observation group were lower than those in the control group,with a statistically significant difference(P<0.05).The good prognosis rate in the observation group was higher than that in the control group,and the difference was statistically significant(P=0.011).Conclusion:Intravenous thrombolysis with alteplase has a significant effect in the treatment of acute cerebral infarction,and can effectively improve coagulation function,alleviate neurological damage,and improve the prognosis of patients.

关 键 词：阿替普酶 静脉溶栓 急性脑梗死 凝血功能 神经功能受损指标 

分 类 号：R741[医药卫生—神经病学与精神病学]