血清sIL-2R、Eotaxin-1在胃癌患者中的表达及与幽门螺旋杆菌感染的相关性  

Expression of serum sIL-2R and Eotaxin-1 in gastric cancer patients and their correlation with Helicobacter pylori infection

作　　者：汝童 王裕麟 胡晓翠 康雪兰 Ru Tong;Wang Yulin;Hu Xiaocui;Kang Xuelan(Department of Gastroenterology,Beidahuang Group General Hospital,Harbin 150000,China)

机构地区：[1]北大荒集团总医院消化内科,哈尔滨150000

出　　处：《疑难病杂志》2024年第7期784-787,共4页Chinese Journal of Difficult and Complicated Cases

基　　金：黑龙江省卫生计生委科研课题(2020-089)。

摘　　要：目的探究胃癌患者血清中可溶性白介素-2受体(sIL-2R)、嗜酸细胞趋化因子1(Eotaxin-1)表达及与幽门螺旋杆菌(Hp)感染的相关性。方法选取2021年7月—2023年8月北大荒集团总医院消化内科收治的胃癌患者118例作为研究组,另选取同期胃部良性病变患者107例作为对照组。ELISA检测血清sIL-2R和Eotaxin-1水平;Hp检测仪检测Hp感染率;采用Spearman法分析患者血清sIL-2R、Eotaxin-1水平与Hp感染的相关性。结果研究组血清sIL-2R和Eotaxin-1水平均高于对照组(t=8.417、7.287,P均<0.001);在有淋巴结转移、分化程度为低分化以及TNM分期为Ⅲ+Ⅳ期患者血清中sIL-2R和Eotaxin-1水平均高于无淋巴结转移、分化程度为中/高分化以及TNM分期为Ⅰ+Ⅱ期患者(sIL-2R:t/P=2.966/0.004、3.164/0.002、2.631/0.010;Eotaxin-1:t/P=2.232/0.028、2.509/0.013、2.613/0.010);研究组Hp阳性率高于对照组(χ^(2)=16.069,P<0.001);伴有Hp感染的患者血清sIL-2R和Eotaxin-1水平均高于Hp阴性患者(t/P=2.111/0.037、5.994/<0.001);Hp感染与血清sIL-2R和Eotaxin-1水平均呈正相关(r=0.405、0.515,P均<0.001)。结论胃癌患者血清中sIL-2R、Eotaxin-1水平升高,两者与Hp感染存在正相关性。Objective To investigate the expression of soluble interleukin-2 receptor(sIL-2R)and Eotaxin-1 in the serum of gastric cancer patients and their correlation with Helicobacter pylori(Hp)infection.Methods One hundred and eighteen gastric cancer patients admitted to the Department of Gastroenterology at Beidahuang Group General Hospital from July 2021 to August 2023 were selected as the study group,and 107 patients with benign gastric lesions during the same period were selected as the control group.ELISA was applied to detect the expression levels of serum sIL-2R and Eotaxin-1;Hp detector was applied to detect Hp infection;Spearman method was applied to analyze the correlation between serum sIL-2R,Eotaxin-1 expression levels and Hp infection in patients.Results The expression levels of serum sIL-2R and Eotaxin-1 in the study group were higher than those in the control group(t=8.417,7.287,P<0.001);The levels of sIL-2R and Eotaxin-1 in the serum of patients with low differentiation,lymph node metastasis,and TNM stageⅢ+Ⅳwere higher than those in patients with medium/high differentiation,no lymph node metastasis,and TNM stageⅠ+Ⅱ(t=2.966,3.164,2.631,P=0.004,0.002,0.010)(t=2.232,2.509,2.613,P=0.028,0.013,0.010);the positive rate of Hp in the study group was higher than that in the control group(χ^(2)=16.069,P<0.001);the expression levels of serum sIL-2R and Eotaxin-1 in patients with Hp infection were higher than those in Hp negative patients(t=2.111,5.994,P=0.037,<0.001);Hp infection was positively correlated with serum sIL-2R and Eotaxin-1 expression levels(r=0.405,0.515,P<0.001).Conclusion The expression levels of sIL-2R and Eotaxin-1 in serum are elevated in gastric cancer patients,and there is a correlation between the two and Hp infection.

关 键 词：胃癌 可溶性白介素-2受体 嗜酸细胞趋化因子1 幽门螺旋杆菌感染 

分 类 号：R735.2[医药卫生—肿瘤]