中药诱导鼻咽癌细胞凋亡机制的研究进展  

Research progress on the mechanism of apoptosis induced by traditional Chinese medicine in nasopharyngeal carcinoma cells

作　　者：陈强 何兰[1] 王贤文[2] Chen Qiang;He Lan;Wang Xianwen(Hunan University of Chinese Medicine,Changsha 410208,China)

机构地区：[1]湖南中医药大学,长沙410208 [2]湖南中医药大学第一附属医院耳鼻咽喉头颈外科,长沙410007

出　　处：《疑难病杂志》2024年第7期883-887,共5页Chinese Journal of Difficult and Complicated Cases

基　　金：国家自然科学基金资助项目(82305329);湖南省自然科学基金(2023JJ30475,2023JJ40500);长沙市自然科学基金资助项目(kq2208206);湖南中医药大学校级课题(2022YYZK010)。

摘　　要：中药治疗肿瘤具有独特的优势,临床上使用中药干预鼻咽癌取得了显著的疗效。细胞凋亡是一种细胞自发性的程序性死亡过程,与肿瘤的发生发展密切相关。现代药理学研究证实,多种中药单体及复方可通过诱导细胞凋亡抑制鼻咽癌发展,但因中药具有多成分、多途径、多环节、多靶点的特性,其诱导鼻咽癌细胞凋亡的机制尚未被完全揭示。文章对中药单体及复方诱导鼻咽癌细胞凋亡的机制进行综述。Traditional Chinese medicine(TCM)has unique advantages in the treatment of tumor,and the use of TCM in clinical intervention of nasopharyngeal carcinoma has achieved remarkable curative effect.Apoptosis is a spontaneous programmed cell death process,which is closely related to the occurrence and development of tumors.Modern pharmacological studies have confirmed that a variety of TCM monomers and compounds can inhibit the development of nasopharyngeal carcinoma by inducing apoptosis,but the mechanism of inducing apoptosis of nasopharyngeal carcinoma cells has not been fully revealed due to the characteristics of TCM with multi-components,multi-pathways,multi-links and multi-targets.By searching,analyzing,summarizing and summarizing the relevant literatures at home and abroad in recent years,the author reviewed the mechanism of inducing apoptosis of nasopharyngeal carcinoma cells by TCM monomer and compound.

关 键 词：鼻咽癌 中药 细胞凋亡 作用机制 

分 类 号：R739.63[医药卫生—肿瘤]