康复新液灌肠对急性放射性直肠炎患者的影响分析  

Analysis of the effect of Kangfuxin liquid enema on patients with acute radiation proctitis

作　　者：张晓霞 张蕾 肖钦丽 ZHANG Xiaoxia;ZHANG Lei;XIAO Qinli(Departmentof Radiotherapy,Henan Cancer Hospital Affiliated to Zhengzhou University,Zhengzhou,Henan)

机构地区：[1]郑州大学附属肿瘤医院(河南省肿瘤医院)放疗科,河南郑州450000

出　　处：《社区医学杂志》2024年第8期258-262,共5页Journal Of Community Medicine

摘　　要：目的探讨康复新液灌肠对急性放射性直肠炎患者直肠黏膜损伤分级程度、炎症水平及肠黏膜细胞抗氧化作用的影响。方法选取2020-08-15-2021-10-15郑州大学附属肿瘤医院急性放射性直肠炎患者106例,随机分为对照组(n=53)和观察组(n=53),对照组给予传统西药保留灌肠,观察组给予康复新液灌肠。于治疗前和治疗2周后,评估并对比2组患者放射性直肠炎黏膜损伤分级程度;于治疗前和治疗2周后,采集2组患者晨间空腹静脉血,采用酶联免疫吸附法检测并对比γ-干扰素(IFN-γ)、白细胞介素-2(IL-2)及白细胞介素-10(IL-10)水平;于治疗前和治疗2周后,采集2组患者晨间空腹静脉血,采用酶联免疫吸附法检测并对比丙二醛(MDA)、超氧化物歧化酶(SOD)水平;记录并对比2组患者不良反应发生情况。使用SPSS23.0分析数据,计数资料用n(%)表示,采用χ^(2)校验;等级资料采用秩和检验,计量资料采用x-±s表示,数据分析采用单因素协方差分析。检验水准α=0.05(双尾)。结果观察组治疗后,放射性直肠炎黏膜损伤分级程度为(0级21例,1级20例,2级10例,3级2例)低于对照组(0级10例,1级23例,2级12例,3级8例),差异有统计学意义,Z=2.540,P=0.011;观察组治疗后IL-2(22.13±2.36)ng/mL水平低于对照组(26.54±2.16)ng/mL,差异有统计学意义,F=10.035,P<0.001;观察组治疗后IFN-γ(27.34±2.37)ng/mL水平低于对照组(31.11±2.24)ng/mL,差异有统计学意义,F=8.416,P<0.001;观察组治疗后IL-10(24.64±2.46)ng/mL水平高于对照组(22.43±2.76)ng/mL,差异有统计学意义,F=4.352,P<0.001;观察组治疗后SOD(61.43±4.55)U/mL水平高于对照组(51.23±4.24)U/mL,差异有统计学意义,F=11.940,P<0.001;观察组治疗后MDA(6.34±1.76)nmol/mL水平低于对照组(10.09±2.124)nmol/mL,差异有统计学意义,F=9.908,P<0.001;治疗期间2组患者均未发生明显不良反应。结论康复新液灌肠对急性放射性直肠炎患者效果确切,能够有效降低放射�Objective To study the effects of Kangfuxin liquid enema on the damage grade and inflammation level of rectal mucosa and the antioxidant activity of intestinal mucosa cells in patients with acute radiation proctitis.Methods A total of 106 patients with acute radiation rectitis in Affiliated Cancer Hospital of Zhengzhou University were randomly divided into control group(n=53)and observation group(n=53).The control group was given traditional Western medicine retention enema,and the observation group was given Kangfuxin liquid enema.Before treatment and 2 weeks after treatment,we evaluated and compared the grade of radiation proctitis mucosa injury in 2 groups.Before treatment and 2 weeks after treatment,the fasting venous blood of 2 groups in the morning was collected,and detected by enzyme-linked immunosorbent assay to compare gamma-interferon(IFN-γ),Interleukin-2(IL-2)and Interleukin-10(interleukin-10).IL-10levels;Before and after 2 weeks of treatment,the fasting venous blood of 2 groups was collected in the morning,and the levels of Malondialdehyde(MDA)and Superoxide dismutase(SOD)were measured by enzyme-linked immunosorbent assay(ELISA).The occurrence of adverse reactions was recorded and compared between the two groups.SPSS23.0 was used to analyze the data,the counting data was represented by n(%),and the difference was tested by χ^(2) test.Rank sum test was used for rank data,x±s was used for measurement data,and univariate covariance analysis was used for data analysis.Test levelα=0.05(two-tailed).Results After treatment,the grade of radiation proctitis mucosa injury in the observation group(21 cases of grade 0,20 cases of grade 1,10 cases of grade 2,2 cases of grade 3)was lower than that in the control group(10 cases of grade 0,23 cases of grade 1,12 cases of grade 2,8 cases of grade 3),the difference was statistically significant Z=2.540,P=0.011.The IL-2(22.13±2.36)ng/mL level in the observation group was lower than that in the control group(26.54±2.16)ng/mL after treatment,and the difference was s

关 键 词：康复新液 急性放射性直肠炎 抗氧化 灌肠 

分 类 号：R574.63[医药卫生—消化系统]