雷珠单抗注射液辅助激光周边虹膜切开术治疗闭角型青光眼的临床研究  

Clinical study of Leizumab injection-assisted LPI surgery in the treatment of angle closure glaucoma

作　　者：兰春燕 赵曼峰 Lan Chunyan;Zhao Manfeng(Department of Ophthalmology,the First Affiliated Hospital of Henan University of Science and Technology,Luoyang 471000,China)

机构地区：[1]河南科技大学第一附属医院眼科,471000

出　　处：《山西医药杂志》2024年第9期647-651,共5页Shanxi Medical Journal

基　　金：河南省医学科技攻关项目(LHGJ202001253)。

摘　　要：目的观察雷珠单抗注射液联合激光周边虹膜切开术(LPL)治疗闭角型青光眼的临床效果。方法本研究为前瞻性研究,选择河南科技大学第一附属医院2021年1月至2023年6月期间收治的112例闭角型青光眼患者为研究对象,基于随机、对照原则,采用计算机分组法将其列为常规组(56例)和联合组(56例),2组患者均实施LPL治疗,联合组采用雷珠单抗注射液辅助治疗,比较2组患者的前房参数,前方周边深度,眼内新生血管参数,眼压、视力恢复情况,及不良事件发生情况。结果在不同治疗方案下,联合组的中央前房深度(CACD)、前房角宽度(ACA)、前房容积(ACV)分别为(1.95±0.27)mm、(26±5)mm、(85±10)mm3,均高于常规组[(1.52±0.31)mm、(22±5)mm、(80±10)mm3];联合组的上方前房深度、下方前房深度、鼻侧前房深度分别为(1.15±0.25)mm、(1.36±0.27)mm、(1.13±0.33)mm,均高于常规组[(0.88±0.42)mm、(0.95±0.31)mm、(0.92±0.31)mm];联合组的肿瘤坏死因子-α(TNF-α)、白细胞介素-1(IL-1)、血管内皮生长因子(VEGF)分别为(30±5)ng/ml、(105±20)pg/ml、(85±10)pg/ml,均低于常规组[(33±5)ng/ml、(120±21)pg/ml、(90±10)pg/ml];联合组治疗1个月、3个月后眼压分别为(20±5)mmHg、(15±3)mmHg,均低于常规组[(23±5)mmHg、(18±4)mmHg];视力分别为(4.28±1.24)、(4.92±1.46),均高于常规组[(3.81±0.82)、(4.33±1.21)];联合组的不良事件发生率7.1%(4/56)低于常规组23.2%(13/56)(P<0.05)。结论雷珠单抗注射辅助LPL术可进一步改善闭角型青光眼患者的前房结构,对抑制眼内新生血管生成、促进眼压及视力恢复并降低不良事件发生风险均有积极意义。Objective To observe the clinical effect of the combination of Leizumab injection and laser peripheral iridoplasty(LPL)in the treatment of angle closure glaucoma.Methods This study is a prospective study.One hundred and twelve patients with angle closure glaucoma admitted to our hospital between January 2021 and June 2023 were selected as the study subjects.Based on a randomized and controlled principle,they were divided into a conventional group(56 cases)and a combination group(56 cases)using the computer grouping method.Both groups received LPL treatment,while the combination group received adjuvant treatment with ranibizumab injection.The anterior chamber parameters and anterior peripheral depth,intraocular neovascularization parameters,intraocular pressure,visual acuity recovery,and incidence of adverse events of the two groups were compared.Results Under different treatment regimens,the central anterior chamber depth(CACD),angle of anterior chamber(ACA),and anterior chamber volume(ACV)of the combination group were(1.95±0.27)mm,(26±5)mm,and(85±10)mm3,which were higher than those in the conventional group[(1.52±0.31)mm,(22±5)mm,and(80±10)mm3].The depth of the upper anterior chamber,lower anterior chamber,and nasal anterior chamber in the combined group were(1.15±0.25)mm,(1.36±0.27)mm,and(1.13±0.33)mm,which were higher than those in the conventional group[(0.88±0.42)mm,(0.95±0.31)mm,and(0.92±0.31)mm].Tumor necrosis factor(TNF)-α、interleukin(IL)-1 and vascular endothelial growth factor(VEGF)of the joint group were(30±5)ng/ml,(105±20)pg/ml,and(85±10)pg/ml,which were lower than those in the conventional group[(33±5)ng/ml,(120±21)pg/ml,and(90±10)pg/ml].After 1 month and 3 months of treatment,the intraocular pressure in the combination group was(20±5)mmHg and(15±3)mmHg,which were lower than those in the conventional group[(23±5)mmHg and(18±4)mmHg].The visual acuity was(4.28±1.24)and(4.92±1.46),which were higher than those in the conventional group[(3.81±0.82)and(4.33±1.21)].The incidence

关 键 词：青光眼 闭角型 前房 雷珠单抗 激光周边虹膜切开术 眼内新生血管 

分 类 号：R779.6[医药卫生—眼科]