宫颈癌患者血清Hsa_circ_0089761的表达及其临床意义  

Expression and clinical significance of serum Hsa_circ_0089761 in cervical cancer patients

作　　者：胡晓华 张文颖[1] 刘峰[1] 何飞燕 严晓春 Hu Xiaohua;Zhang Wenying;Liu Feng;He Feiyan;Yan Xiaochun(Department of Oncology,the Ninth People′s Hospital Affiliated to Shanghai Jiaotong University School of Medicine,Shanghai 201900,China;Department of Obstetrics and Gynecology,the Ninth People′s Hospital Affiliated to Shanghai Jiaotong University School of Medicine,Shanghai 201900,China)

机构地区：[1]上海交通大学医学院附属第九人民医院肿瘤科,上海201900 [2]上海交通大学医学院附属第九人民医院妇产科,上海201900

出　　处：《中国医师杂志》2024年第6期890-894,共5页Journal of Chinese Physician

摘　　要：目的探讨宫颈癌患者血清Hsa_circ_0089761表达水平及其临床意义。方法选取2021年1月至2023年3月上海交通大学医学院附属第九人民医收治的宫颈癌患者107例、宫颈上皮内瘤变(CIN)患者80例和正常对照组60例进行分析。比较各组血清Hsa_circ_0089761、鳞状上皮细胞癌抗原(SCCA)及癌胚抗原(CEA)水平,分析血清Hsa_circ_0089761表达水平与宫颈癌临床病理特征的关系。绘制受试者工作特征(ROC)曲线分析血清Hsa_circ_0089761、SCCA及CEA水平对宫颈癌的诊断价值。采用Pearson相关分析法评估宫颈癌患者血清Hsa_circ_0089761表达水平与SCCA及CEA的相关性。结果宫颈癌组血清Hsa_circ_0089761[(2.96±0.95)vs(1.83±0.74),(0.92±0.41)]、SCCA[(9.63±1.84)ng/ml vs(2.28±0.65)ng/ml,(1.30±0.27)ng/ml]及CEA[(6.47±2.20)ng/ml vs(1.61±0.57)ng/ml,(1.15±0.12)ng/ml]水平均明显高于CIN组和对照组(均P<0.001),CIN组血清Hsa_circ_0089761表达水平明显高于对照组(P<0.001)。Ⅲ~Ⅳ期、低分化、淋巴结转移、浸润深度≥1/2肌层、SCCA阳性以及CEA阳性的宫颈癌患者血清Hsa_circ_0089761表达水平明显更高(均P<0.05)。ROC曲线分析显示,Hsa_circ_0089761≥2.25诊断宫颈癌的特异度最高(85.00%),Hsa_circ_0089761联合SCCA诊断宫颈癌的ROC曲线下面积(AUC)最大(0.932,95%CI:0.874~0.993),准确度最高(89.30%),Hsa_circ_0089761+SCCA+CEA三项联合诊断宫颈癌的灵敏度最高(96.26%)。相关性分析结果显示,宫颈癌患者血清Hsa_circ_0089761表达水平与SCCA(r=0.775,P<0.001)及CEA(r=0.613,P<0.001)呈正相关。结论宫颈癌患者血清Hsa_circ_0089761表达水平明显升高,其升高与临床病理特征有关,Hsa_circ_0089761联合SCCA检测对宫颈癌诊断具有较高的价值。Objective To explore the expression level and clinical significance of serum Hsa_circ_0089761 in patients with cervical cancer.Methods A total of 107 cervical cancer patients,80 cervical intraepithelial neoplasia(CIN)patients,and 60 normal control group were selected and analyzed from January 2021 to March 2023 at the Ninth Affiliated People's Hospital of Shanghai Jiao Tong University School of Medicine.We compared the levels of serum Hsa_circ_0089761,squamous cell carcinoma antigen(SCCA),and carcinoembryonic antigen(CEA)among different groups,and analyzed the relationship between the expression level of serum Hsa_circ_0089761 and the clinical and pathological characteristics of cervical cancer.The receiver operating characteristic(ROC)curve was drawn to analyze the diagnostic value of serum Hsa_circ_0089761,SCCA,and CEA levels for cervical cancer.Pearson correlation analysis was used to evaluate the correlation between serum Hsa_circ_0089761 expression levels and SCCA and CEA in cervical cancer patients.Results The expression levels of serum Hsa_circ_0089761[(2.96±0.95)vs(1.83±0.74),(0.92±0.41)],SCCA[(9.63±1.84)ng/ml vs(2.28±0.65)ng/ml,(1.30±0.27)ng/ml],and CEA[(6.47±2.20)ng/ml vs(1.61±0.57)ng/ml,(1.15±0.12)ng/ml]in the cervical cancer group were significantly higher than those in the CIN group and the control group(all P<0.001),and the serum Hsa_circ_0089761 expression levels in the CIN group were significantly higher than those in the control group(P<0.001).Cervical cancer patients in stagesⅢ-Ⅳ,with low differentiation,lymph node metastasis,infiltration depth≥1/2 of the muscle layer,positive SCCA,and positive CEA had significantly higher levels of serum Hsa_circ_0089761 expression(all P<0.05).The ROC curve analysis showed that the specificity of diagnosing cervical cancer was highest(85.00%)for Hsa_circ_0089761≥2.25,and the area under the ROC curve(AUC)for diagnosing cervical cancer in combination with SCCA was highest(0.932,95%CI:0.874-0.993),with the highest accuracy(89.30%).The sensitivity

关 键 词：宫颈肿瘤 RNA 环状 Hsa_circ_0089761 

分 类 号：R737.33[医药卫生—肿瘤]