氯吡格雷联合低分子肝素钙对进展性缺血性脑卒中的治疗效果分析  

Effect analysis of clopidogrel combined with low molecular weight heparin calcium in the treatment of progressive ischemic stroke

作　　者：王新征 李秀芹 WANG Xin-zheng;LI Xiu-qin(Huantai County Maternal and Child Health Hospital,Zibo 256400,China)

机构地区：[1]桓台县妇幼保健院,256400

出　　处：《中国实用医药》2024年第12期98-101,共4页China Practical Medicine

摘　　要：目的 探究进展性缺血性脑卒中应用氯吡格雷+低分子肝素钙联合治疗的效果。方法 100例进展性缺血性脑卒中患者,依据差异化治疗方案分为对照组(低分子肝素钙单药治疗)和观察组(氯吡格雷+低分子肝素钙联合治疗),各50例。比较两组美国国立卫生研究院卒中量表(NHISS)评分、血液流变学指标、生活质量水平、临床效果及安全性。结果 治疗后两组NIHSS评分均较治疗前明显降低,且观察组NIHSS评分(9.33±2.89)分低于对照组的(12.42±3.11)分,差异值显著(P<0.05)。治疗后两组纤维蛋白原、血浆粘度、血小板聚集率均较治疗前明显降低,且观察组纤维蛋白原(2.12±0.43)g/L、血浆粘度(1.09±0.27)mPa·s、血小板聚集率(34.46±15.62)%低于对照组的(2.73±0.55)g/L、(1.31±0.34)mPa·s、(51.22±20.31)%,差异值显著(P<0.05)。治疗后两组生理维度、心理维度、社会功能维度、物质水平维度评分均较治疗前升高,且观察组明显高于对照组,差异值显著(P<0.05)。观察组临床总有效率96.00%(48/50)高于对照组的82.00%(41/50),差异值显著(P<0.05)。观察组不良反应发生率6.00%低于对照组的20.00%,差异值显著(P<0.05)。结论 针对进展性缺血性脑卒中患者,临床给予氯吡格雷、低分子肝素钙联合治疗,相比单药治疗在改善血液流变学指标、神经功能缺损及降低不良反应方面成效显著,生活质量亦明显提升,值得临床积极推广应用。Objective To explore the effect of clopidogrel combined with low molecular weight heparin calcium in the treatment of progressive ischemic stroke.Methods A total of 100 patients with progressive ischemic stroke were divided into a control group(low molecular weight heparin calcium)and an observation group(clopidogrel combined with low molecular weight heparin calcium)according to the differentiated treatment plan,with 50 cases in each group.The National Institutes of Health Stroke Scale(NHISS)score,blood rheology indices,quality of life levels,clinical outcomes and safety were compared between the two groups.Results After treatment,NIHSS score in both groups was significantly lower than that before treatment,and the observation group had lower NIHSS score of(9.33±2.89)points than(12.42±3.11)points in the control group.The difference was significant(P<0.05).After treatment,the fibrinogen,plasma viscosity and platelet aggregation rate in both groups were significantly decreased compared with those before treatment;the observation group had fibrinogen of(2.12±0.43)g/L,plasma viscosity of(1.09±0.27)mPa·s and platelet aggregation rate of(34.46±15.62)%,which were lower than(2.73±0.55)g/L,(1.31±0.34)mPa·s and(51.22±20.31)%in the control group;the difference was significant(P<0.05).After treatment,the scores of physiological dimension,psychological dimension,social function dimension and substance level dimension in both groups were higher than those before treatment,and the observation group was significantly higher than the control group.The difference was significant(P<0.05).The total clinical effective rate of the observation group was 96.00%(48/50),which was higher than 82.00%(41/50)of the control group,and the difference was significant(P<0.05).The incidence of adverse reactions in the observation group was 6.00%,which was lower than 20.00%in the control group,and the difference was significant(P<0.05).Conclusion For patients with progressive ischemic stroke,the combination therapy of clopidogrel and low

关 键 词：进展性缺血性脑卒中 低分子肝素钙 氯吡格雷 神经功能缺损 

分 类 号：R743.3[医药卫生—神经病学与精神病学]