利培酮联合奥氮平对精神分裂症患者甲状腺激素水平的影响分析  

Effect analysis of risperidone combined with olanzapine on thyroid hormone levels in patients with schizophrenia

作　　者：王勤 WANG Qin(The Fourth People's Hospital of Yancheng City,Yancheng 224003,China)

机构地区：[1]盐城市第四人民医院,224003

出　　处：《中国实用医药》2024年第12期128-130,共3页China Practical Medicine

摘　　要：目的 分析利培酮和奥氮平联合对精神分裂症患者甲状腺激素水平的影响。方法 90例精神分裂症患者,均进行利培酮联合奥氮平治疗。对比患者治疗前后甲状腺激素水平。结果 患者治疗后,血清三碘甲状腺原氨酸(2.21±0.39)nmol/L、甲状腺素(136.18±22.52)nmol/L、游离三碘甲状腺原氨酸(4.10±1.39)pmol/L、游离甲状腺素(18.08±5.29)pmol/L以及促甲状腺激素(4.08±0.95)mIU/L均高于治疗前的(1.69±0.51)nmol/L、(88.18±23.26)nmol/L、(2.81±1.14)pmol/L、(11.21±2.44)pmol/L、(2.76±0.51)mIU/L,具有统计学差异(P<0.05)。结论 利培酮联合奥氮平对精神分裂症患者疗效确切,但是需要密切监测甲状腺激素水平和药物的不良反应,以确保治疗的安全性和有效性。Objective To analyze the effect of risperidone combined with olanzapine on thyroid hormone levels in patients with schizophrenia.Methods 90 schizophrenic patients were collected,and risperidone combined with olanzapine was provided for treatment.The thyroid hormone levels before and after treatment were compared.Results After treatment,patients had serum triiodothyronine of(2.21±0.39)nmol/L,thyroxine of(136.18±22.52)nmol/L,free triiodothyronine of(4.10±1.39)pmol/L,free thyroxine of(18.08±5.29)pmol/L and thyroid stimulating hormone of(4.08±0.95)mIU/L,which were higher than(1.69±0.51)nmol/L,(88.18±23.26)nmol/L,(2.81±1.14)pmol/L,(11.21±2.44)pmol/L and(2.76±0.51)mIU/L before treatment.There was statistical difference(P<0.05).Conclusion Risperidone combined with olanzapine is effective in patients with schizophrenia,but close monitoring of thyroid hormone levels and adverse drug reactions is needed to ensure the safety and efficacy of treatment.

关 键 词：精神分裂症 利培酮 奥氮平 甲状腺激素 

分 类 号：R749.3[医药卫生—神经病学与精神病学]