抑郁症患者无抽搐电休克治疗期间认知功能变化规律及影响因素分析  

作　　者：费银霞 程善飞[1] 沈银萍 

机构地区：[1]浙江省湖州市第三人民医院,313000

出　　处：《浙江临床医学》2024年第6期837-839,共3页Zhejiang Clinical Medical Journal

基　　金：浙江省医药卫生科技计划项目(2023KY1186);湖州市科技计划项目(2018GYB54)。

摘　　要：目的探讨抑郁症患者无抽搐电休克治疗(mECT)期间认知功能的变化规律及影响因素。方法采用便利抽样法对209例mECT期间抑郁症患者12个不同时间点(治疗前、术前、急性期的1周、2周末、急性期末、维持期的1周、2周、4周、6周、8周、12周、16周)应用认知评估量表(MMSE)进行认知功能评估,绘制mECT期间认知功能变化曲线,并对患者治疗期间认知功能变化进行单因素分析和多元回归分析。结果12个不同时间点患者认知功能平均得分为(26.19±2.91)分,患者认知功能低值出现在急性治疗期,整个治疗周期结束时认知功能得分高于治疗前。认知功能变化的影响因素有患者的年龄、病程及抑郁程度(P<0.05)。结论抑郁症患者mECT期间,认知功能随时间呈两端高急性期低的态势,医务人员应根据认知功能的变化曲线及影响因素实施个体化、有针对性的指导,缓解患者及家属的负性情绪,从而提高mECT的积极性。Objective To explore the changes in cognitive function and influencing factors during non-convulsive electroconvulsive therapy(mECT)in patients with depression.Method A convenience sampling method was used to investigate cognitive function in 209 patients with depression during MECT at 12 different time points(before treatment,before surgery,1 week and 2 weeks of acute phase,at the end of acute phase,1 week,2 weeks,4 weeks,6 weeks,8 weeks,12 weeks,and 16 weeks of maintenance phase)using the Cognitive Assessment Scale(MMSE).A curve of cognitive function change during mECT was drawn.Univariate analysis and multiple regression analysis on the cognitive function changes of patients during treatment was conducted.Results During the mECT period,the average score of the patient's cognitive function was 26.19±2.91.The low value of the patient's cognitive function occurred during the acute treatment period,and the cognitive function score was higher at the end of the entire treatment cycle than before the treatment.The influencing factors of cognitive function changes include the patient's age,course of disease,and degree of depression(P<0.05).Conclusion During the mECT period of depression patients,cognitive function showed a trend of high at both ends and low at the acute stage over time.Medical staff should implement personalized and targeted guidance based on the curve of cognitive function changes and influencing factors,alleviate the negative emotions of patients and their families,and thus improve the enthusiasm of mECT.

关 键 词：抑郁症 认知功能 影响因素 

分 类 号：R749.4[医药卫生—神经病学与精神病学]