精神分裂症患者血清尿酸和认知功能的相关性分析  

作　　者：郑克[1] 潘安乐 吕伟 潘建设[1] 叶晓丹 刘家洪[1] 陈楚楚 朱程 

机构地区：[1]温州医科大学附属康宁医院,325000 [2]浙江中医药大学,310053

出　　处：《浙江临床医学》2024年第6期889-890,893,共3页Zhejiang Clinical Medical Journal

基　　金：温州市基础性公益科研项目(Y20220839)。

摘　　要：目的观察精神分裂症患者血清尿酸的变化,探讨及其与认知功能的相关性。方法采用重复性成套神经心理状态监测量表(RBANS)评估71例精神分裂症患者(分裂症组)和37例性别及年龄匹配的健康者(对照组)的认知功能,同时采用尿酸酶-过氧化物法检测所有受试者的血清尿酸水平。结果将性别、年龄、文化程度和BMI作为协变量控制后,分裂症组血清尿酸、即刻记忆、注意、言语、延迟记忆和RBANS总分均低于对照组(P<0.05)。相关性分析发现分裂症组血清尿酸水平与即刻记忆和注意存在相关性(P<0.001);多元线性回归方程显示分裂症组血清尿酸与即刻记忆和注意存在正相关(P<0.05)。结论精神分裂症患者血清尿酸下降可能参与认知损伤的病理过程。Objective To investigate the changes in serum uric acid(UC)levels in patients with schizophrenia and explore its correlation with cognitive function Methods A total of 71 schizophrenia patients and 37 healthy controls were recruited.Cognitive functions were measured by the Repeatable Battery for the Assessment of Neuropsychological(RBANS),and serum UC levels were also estimated.Results The patients with schizophrenia had significantly lower scores on the nearly all of RBANS(i.e.,immediate memory,language,attention,delayed memory,and total score of RBANS)and serum UC levels than healthy controls after adjusting for variables(P<0.05).Pearson's correlation analyses showed that serum UC levels were positively associated with immediately memory and attention scores in schizophrenic patient(P<0.001).Furthermore,multivariate regression analyses showed that serum UC levels were positively associated with immediately memory and attention(P<0.05).Conclusion Reduced serum UC levels might be implicated in the pathophyology of cognitive impairments in schizophrenia.

关 键 词：尿酸 精神分裂症 认知功能 

分 类 号：R749.3[医药卫生—神经病学与精神病学]