核苷酸结合寡聚化结构域样受体介导相关炎症因子与HPV相关宫颈癌的关联  

Association of nucleotide-binding oligomerization domain-like receptor-mediated inflammatory factors with cervical cancer caused by HPV

作　　者：张莎莎 张玮璨 刘鑫 赵卉 申佳伟 ZHANG Sha-sha;ZHANG Wei-can;LIU Xin;ZHAO Hui;SHEN Jia-wei(Xingtai People's Hospital,Xingtai,Hebei 054000,China;不详)

机构地区：[1]邢台市人民医院产科,河北邢台054000 [2]邢台市中医院妇科,河北邢台054003

出　　处：《中华医院感染学杂志》2024年第12期1841-1844,共4页Chinese Journal of Nosocomiology

基　　金：河北省医学科学研究重点课题计划基金资助项目(20210379)。

摘　　要：目的研究核苷酸结合寡聚化结构域(NOD)样受体介导相关炎症因子表达与人乳头瘤病毒(HPV)相关宫颈癌的关系.方法选取邢台市人民医院2022年1月-2023年1月收治的120例宫颈病变患者,其中良性病变60例,恶性病变60例,均行子宫切除术;于术中获取宫颈癌组织、良性病变宫颈组织,检测宫颈组织NOD1、NOD2 mRNA表达情况及血清肿瘤坏死因子-α(TNF-α)、白细胞介素-1β(IL-1β)、IL-6、IL-18蛋白表达水平;比较良性病变、恶性病变各炎性因子表达水平,以及分析各炎性因子的表达水平与宫颈癌分级、高危人乳头瘤病毒(HR-HPV)感染的关系.结果恶性病变患者的NOD1、NOD2 mRNA及TNF-α、IL-1β、IL-6、IL-18蛋白表达水平高于良性病变患者(P<0.05);随着宫颈癌分级程度的增加,宫颈癌患者的NOD1、NOD2 mRNA及TNF-a、IL-1β、IL-6、IL-18蛋白表达水平呈增加趋势,且Ⅰ~Ⅲ级患者的NOD样受体介导相关炎症因子表达水平差异有统计学意义(P<0.05);入组60例恶性病变患者中,HR-HPV感染40例,其中HR-HPV阳性患者的NOD1、NOD2 mRNA及TNF-α、IL-1β、IL-6、IL-18蛋白表达水平高于HR-HPV阴性患者(P<0.05).结论宫颈癌的发生与HR-HPV的持续感染密切相关,HR-HPV感染可介导NOD样受体介导相关炎症因子的表达,进而参与宫颈癌的发生发展.OBJECTIVE To investigate the association of nucleotide-binding oligomerization domain(NOD)-like receptor-mediated inflammatory factor expressions with human papillomavirus(HPV)-associated cervical cancer.METHODS Totally 120 patients with cervical lesions admitted to Xingtai People's Hospital from Jan.2022 to Jan.2023 were selected,including 60 cases of benign lesions and 60 cases of malignant lesions.All patients underwent hysterectomy,and cervical cancer tissue and benign cervical tissue were obtained during the surgery,and the expression of NOD1 and NOD2 mRNA in cervical tissues,as well as the expression levels of tumor necrosis factor-α(TNF-α),interleukin-1β(IL-1p),IL-6 and IL-18 protein were detected.The expression levels of inflammatory factors in benign lesions and malignant lesions were compared,and the relationship between the expression levels of inflammatory factors and cervical cancer grade and high-risk human papillomavirus(HR-HPV)infection was analyzed.RESULTS The expression levels of NOD1 and NOD2 mRNA and TNF-α,IL-1β,IL-6 and IL-18 protein in patients with malignant lesions were significantly higher than those in patients with benign lesions(P<0.05).With the increase of the degree of cervical cancer grading,the expression levels of NOD1 and NOD2 mRNA and TNF-α,IL-1p,IL-6 and IL-18 protein in patients with cervical cancer showed an increasing trend,and the differences in the expression levels of NOD-like receptor-mediated related inflammatory factors in patients with grade I-II were statistically significant(P<0.05).Among the 60 patients with malignant lesions enrolled in the group,there were 4O cases of HR-HPV infection,of which the expression levels of NODl and NOD2 mRNA and TNF-α,IL-1β,IL-6 and IL-18 protein in HR-HPV-positive patients were significantly higher than those in HRHPV-negative patients(P<0.05).CONCLUSION The occurrence of cervical cancer was closely related to the persistent infection of HR-HPV,which mediated the expression of NOD-like receptors mediating related inflammatory

关 键 词：核苷酸结合寡聚化结构域 炎症因子 人乳头瘤病毒 感染 宫颈癌 

分 类 号：R737.33[医药卫生—肿瘤]