疏肝解郁胶囊联合艾司西酞普兰治疗轻中度单相抑郁症临床研究  

Clinical Study on Shugan Jieyu Capsules Combined with Escitalopram Oxalate for Mild to Moderate Unipolar Depression

作　　者：刘凤雏 张波 李群潇 钱利华 LIU Fengchu;ZHANG Bo;LI Qunxiao;QIAN Lihua(Graduate School of Zhejiang Chinese Medical University,Hangzhou Zhejiang 310053,China;Department of Psychiatry,The Third People's Hospital of Fuyang,Hangzhou Zhejiang 311400,China;Laboratory Department,The Third People's Hospital of Fuyang,Hangzhou Zhejiang 311400,China)

机构地区：[1]浙江中医药大学研究生院,浙江杭州310053 [2]杭州市富阳区第三人民医院精神科,浙江杭州311400 [3]杭州市富阳区第三人民医院检验科,浙江杭州311400

出　　处：《新中医》2024年第11期29-33,共5页New Chinese Medicine

摘　　要：目的:观察疏肝解郁胶囊联合艾司西酞普兰治疗轻中度单相抑郁症的临床疗效及对血清去甲肾上腺素(NE)、5-羟色胺(5-HT)水平和神经功能的影响。方法:选择120例单相抑郁症轻中度患者为研究对象,按随机数字表法分为研究组和对照组各60例。对照组给予艾司西酞普兰口服,研究组在对照组基础上给予疏肝解郁胶囊口服,持续服药8周。评价2组临床疗效,比较2组治疗前后美国国立卫生研究院卒中量表(NIHSS)评分及血清NE、5-HT、白细胞介素-1β(IL-1β)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)水平,观察不良反应发生情况。结果:2组总有效率比较,差异无统计学意义(P>0.05)。治疗后,2组血清NE、5-HT水平较治疗前升高(P<0.05),且研究组血清NE、5-HT水平高于对照组(P<0.05)。治疗后,2组NIHSS评分较治疗前降低(P<0.05),且研究组NIHSS评分低于对照组(P<0.05)。治疗后,2组血清IL-1β、TNF-α、IL-6水平较治疗前降低(P<0.05),且研究组血清IL-1β、TNF-α、IL-6水平低于对照组(P<0.05)。研究组不良反应发生率低于对照组(P<0.05)。结论:疏肝解郁胶囊联合艾司西酞普兰治疗轻中度单相抑郁症能有效改善血清NE、5-HT水平,降低炎症因子的表达,提高神经功能。Objective:To observe the clinical effect of Shugan Jieyu Capsules combined with Escitalopram Oxalate on mild to moderate unipolar depression and its effects on the levels of noradrenaline(NE)and 5-hydroxytryptamine(5-HT)in serum and neurological function.Methods:A total of 120 cases of patients with mild to moderate unipolar depression were selected as the study objects,and were divided into the study group and the control group according to the random number table method,with 60 cases in each group.The control group was given the oral administration of Escitalopram Oxalate,and the study group was additionally given the oral administration of Shugan Jieyu Capsules based on the treatment of the control group.Both groups were treated for eight weeks.The clinical effects in the two groups were evaluated;the National Institutes of Health Stroke Scale(NIHSS)scores and the levels of NE,5-HT,interleukin-1β(IL-1β),tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6)in serum were compared before and after treatment between the two groups;the incidence of adverse reactions was observed.Results:There was no significant difference being found in the comparison of the total effective rates between the two groups(P>0.05).After treatment,the levels of NE and 5-HT in serum in the two groups were increased when compared with those before treatment(P<0.05),and the levels of NE and 5-HT in serum in the study group were higher than those in the control group(P<0.05).After treatment,NIHSS scores in the two groups were decreased when compared with those before treatment(P<0.05),and the NIHSS score in the study group was lower than that in the control group(P<0.05).After treatment,the levels of IL-1β,TNF-αand IL-6 in serum in the two groups were decreased when compared with those before treatment(P<0.05),and levels of IL-1β,TNF-αand IL-6 in serum in the study group were lower than those in the control group(P<0.05).The incidence of adverse reactions in the study group was lower than that in the control group(P<0.05).Conclusion

关 键 词：单相抑郁症 轻中度 疏肝解郁胶囊 去甲肾上腺素 5-羟色胺 神经功能 不良反应 

分 类 号：R749.05[医药卫生—神经病学与精神病学]