子宫内膜癌及子宫内膜不典型增生患者分子分型特征与宫腔镜治疗疗效和临床病理特征关系研究  

A study analysing the molecular typing characteristics of patients with endometrial cancer and endometrial atypical hyperplasia in relation to the efficacy of hysteroscopic treatment and clinicopathological features.

作　　者：李冰[1] 习开超 高丽丽 LI Bing;XI Kai-chao;GAO Li-li(Department of Obstetrics and Gynecology,Tangshan Maternal and Child Health Hospital,Tangshan 063000,China;不详)

机构地区：[1]唐山市妇幼保健院妇产科,河北唐山063000 [2]唐山市妇幼保健院放射科,河北唐山063000

出　　处：《中国实用妇科与产科杂志》2024年第6期661-664,共4页Chinese Journal of Practical Gynecology and Obstetrics

基　　金：卫生部医药卫生科技项目(13010520190917)。

摘　　要：目的探讨子宫内膜癌(EC)及子宫内膜不典型增生(EAH)患者的分子分型特征与宫腔镜治疗疗效和临床病理特征关系。方法选取2018年1月至2021年1月就诊于唐山市妇幼保健院的EC(75例)与EAH(81例)患者为研究对象,所有患者均接受宫腔镜下子宫内膜病灶切除术联合孕激素治疗,收集两组患者的各基线资料和病理学资料,利用logistic回归分析不同分子分型特征、临床病理特征与治疗效果的关系,构建EC与EAH预后的预测模型。结果治疗总有效率EC患者为85.33%(64/75),EAH患者为80.25%(65/81)。logistic回归分析结果显示,淋巴结转移(OR=4.265,P=0.003)、临床分期(OR=2.859,P=0.021)是影响EC患者治疗疗效的独立危险因素(P<0.05),雌激素受体(OR=3.582,P=0.013)是影响EAH患者治疗疗效的独立危险因素(P<0.05)。结论淋巴结转移、临床分期及雌孕激素受体情况影响EC患者不同分子分型的治疗疗效,雌孕激素受体情况影响EAH患者的生育功能治疗疗效。Objective To investigate the molecular typing characteristics of patients with endometrial cancer(EC)and endometrial atypical hyperplasia(EAH)in relation to the efficacy of hysteroscopic treatment and clinicopathological fea⁃tures.Methods EC(75 cases)and EAH(81 cases)patients who visited Tangshan Maternal and Child Health Hospital from January 2018 to January 2021 were selected as the research subjects.All patients received hysteroscopic endometri⁃al lesion resection combined with progesterone treatment.The baseline and pathological data of the two groups of patients were collected,and logistic regression was used to analyse the relationship between the different molecular typing fea⁃tures,clinicopathological features and treatment effects,and to construct the predictive model for the prognosis of EC and EAH.Results The total effective rate for EC was 85.33%(64/75)and 80.25%(65/81)for EAH.The results of logical re⁃gression analysis showed that lymph node metastasis(OR=4.265,P=0.003)and clinical stage(OR=2.859,P=0.021)were independent risk factors affecting the therapeutic efficacy of EC patients(P<0.05),and estrogen receptor(OR=3.582,P=0.013)were independent risk factors affecting the therapeutic efficacy of EAH patients(P<0.05).Conclusion Lymph node metastasis,clinical stage and estrogen receptor status affects the efficacy of treatment in different molecu⁃lar typing of EC patients,and estrogen receptor status affects the efficacy of fertility treatment in EAH patients.

关 键 词：子宫内膜癌 子宫内膜不典型增生 分子分型特征 临床病理特征 

分 类 号：R737.3[医药卫生—肿瘤]