HMGB1基因调控胶质瘤恶性生物学行为研究进展  

Progress on the regulation of malignant biological behavior of glioma by HMGB1 gene

作　　者：王军成 赵岳阳[2] 杨强 蒯涛[4] 潘亚文[3,5] Jun-cheng WANG;Yue-yang ZHAO;Qiang YANG;Tao KUAI;Ya-wen PAN(The Second College for Clinical Medicine,Lanzhou University,Lanzhou 730030,Gansu,China;Department of Oncology,People's Hospital of Ningxia Hui Autonomous Region,Yinchuan 750001,Ningxia,China;Department of Neurosurgery,Lanzhou University Second Hospital,Lanzhou 730030,Gansu,China;Department of Neurosurgery,People's Hospital of Ningxia Hui Autonomous Region,Yinchuan 750001,Ningxia,China;Institute of Neurology,Lanzhou University,Lanzhou 730030,Gansu,China)

机构地区：[1]兰州大学第二临床医学院,730030 [2]宁夏回族自治区人民医院肿瘤科,银川750001 [3]兰州大学第二医院神经外科,730030 [4]宁夏回族自治区人民医院神经外科,银川750001 [5]兰州大学神经病学研究所,730030

出　　处：《中国现代神经疾病杂志》2024年第5期391-397,共7页Chinese Journal of Contemporary Neurology and Neurosurgery

基　　金：宁夏回族自治区自然科学基金项目(项目编号:2021AAC03313);2021年第六批宁夏回族自治区青年科技人才托举工程;宁夏医科大学科学研究基金资助项目(项目编号:XM2020087);宁夏回族自治区人民医院国家自然科学基金预实验项目(项目编号:2021GZRYSY017)。

摘　　要：胶质瘤因其复杂的生物学特性以及胶质瘤干细胞的干细胞特性,标准治疗后易复发。高迁移率族蛋白1(HMGB1)作为癌基因通过多种不同方式参与调控胶质瘤恶性进展。本文对HMGB1基因与胶质瘤预后、肿瘤病理分级、干细胞相关性以及HMGB1基因调控胶质瘤方式如非编码RNA途径、细胞自噬途径、肿瘤微环境等进行综述,为胶质瘤的治疗提供参考。Glioma is often recurred after standard treatment due to its complex biological characteristics and the presence of glioma stem cells(GSCs).High-mobility group box 1(HMGB1)can regulate the malignant progression of glioma through a variety of ways as an oncogene.This article reviews the relationship between HMGB1 gene and the prognosis of glioma patients,tumor pathological grading,GSCs,and the ways including non coding RNA pathway,autophagy pathway,tumor microenvironment,etc.,in which HMGB1 gene regulates glioma,so as to provide the reference for the treatment of glioma.

关 键 词：神经胶质瘤 HMGB1蛋白质 RNA 未翻译 自噬 肿瘤微环境 综述 

分 类 号：R739.41[医药卫生—肿瘤]