非^(18)F-FDG PET分子显像在淋巴瘤中的应用进展  

Application progress of non-^(18)F-FDG PET molecular imaging in lymphoma

作　　者：廖思锶 赵晋华[1] Liao Sisi;Zhao Jinhua(Department of Nuclear Medicine,Shanghai General Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200080,China)

机构地区：[1]上海交通大学医学院附属第一人民医院核医学科,上海200080

出　　处：《国际放射医学核医学杂志》2024年第3期198-203,共6页International Journal of Radiation Medicine and Nuclear Medicine

摘　　要：淋巴瘤是一种起源于淋巴结和淋巴组织的免疫系统恶性肿瘤,具有起病隐匿、侵袭性强等特点,是我国发病率增速最快的肿瘤之一。目前,^(18)F-FDG PET/CT已经成为恶性淋巴瘤初始分期、再分期、早期治疗反应及疗效评估、预后预测与随访的重要影像技术。由于淋巴瘤的异质性,如侵袭性、组织来源、免疫表型、病程阶段、不同人群治疗反应等的差异,非^(18)F-FDG PET分子显像技术在一些特定类型淋巴瘤的靶向诊疗中表现出较^(18)F-FDG PET/CT更明显的优势。笔者聚焦于非^(18)F-FDG PET分子显像在淋巴瘤中的研究进展,比较了非^(18)F-FDG显像剂与传统显像剂^(18)F-FDG在淋巴瘤诊疗过程中的异同、优势与不足、应用特色和发展潜能,期望为淋巴瘤特异性靶向诊疗和个性化精准医疗提供新的思路和方法。Lymphoma is a malignant tumor of the immune system originating from lymph nodes and lymphoid tissues.It is characterized by insidious onset and strong invasion,and is one of the tumors with the fastest growing incidence rate in China.At present,^(18)F-FDG PET/CT has been an important imaging technique for the initial staging,re-staging,early treatment response,efficacy evaluation,prognosis prediction,and follow-up of malignant lymphoma.Due to the heterogeneity of lymphoma,such as different types of lymphoma in invasiveness,tissue origins,immune phenotypes,the stage of disease,and treatment response of different populations,non-^(18)F-FDG PET molecular imaging technologies are expected to show advantages over^(18)F-FDG PET/CT in the targeted diagnosis and treatment of some specific types of lymphoma.The authors focused on the research progress of non-^(18)F-FDG PET molecular imaging in lymphoma,comparing the similarities and differences,advantages and disadvantages,application characteristics and development potentials between non-^(18)F-FDG imaging agents and traditional imaging agent^(18)F-FDG in the diagnosis and treatment of lymphoma,so as to provide new ideas and methods for the specific targeted diagnosis and treatment and personalized precision medicine of lymphoma.

关 键 词：淋巴瘤 氟脱氧葡萄糖F18 正电子发射断层显像术 分子显像 靶向诊疗 

分 类 号：R733.1[医药卫生—肿瘤] R730.44[医药卫生—临床医学]