癫痫患者脑电图异常与血液miR-130b-3p和miR-7及FGL2表达特征的关系  

Relationship between abnormal EEG and expression characteristics of miR-130b-3p,miR-7,and FGL2 in patients with epilepsy

作　　者：张力辉 韩东岳 孙树敏 罗晓晨 ZHANG Lihui;HAN Dongyue;SUN Shumin;LUO Xiaochen(Department of Brain Disease,Qinhuangdao Integrated Traditional Chinese and Western Medicine Hospital,Qinhuangdao 066000,Hebei,China)

机构地区：[1]秦皇岛中西医结合医院脑病一科,河北秦皇岛066000

出　　处：《贵州医科大学学报》2024年第6期846-851,共6页Journal of Guizhou Medical University

基　　金：河北省医学科学研究课题计划项目(20212510)。

摘　　要：目的探讨癫痫患者脑电图异常与血液miR-130b-3p、miR-7及纤维蛋白原样蛋白2(FGL2)表达特征的关系。方法选取接受治疗的癫痫患者124例作为观察组(癫痫发作轻度患者36例、中度患者51例及重度患者37例,脑电图轻度异常患者65例、中度异常35例及重度异常24例),同时选取体检健康者120例作为对照组;比较观察组和对照组、不同程度癫痫发作患者、不同程度脑电图异常的癫痫患者血液miR-130b-3p、miR-7及FGL2表达差异,分析癫痫患者血液miR-130b-3p、miR-7及FGL2与疾病程度和脑电图异常的相关性。结果观察组miR-130b-3p、FGL2高于对照组(P<0.05),miR-7低于对照组(P<0.05);癫痫发作重度患者miR-130b-3p、FGL2高于轻度和中度患者(P<0.05),miR-7低于轻度和中度患者(P<0.05);全面性癫痫发作患者miR-130b-3p、FGL2高于部分性发作患者(P<0.05);脑电图重度异常癫痫患者miR-130b-3p、FGL2高于脑电图轻度和中度异常患者(P<0.05),miR-7低于轻度和中度异常患者(P<0.05);脑电图中度异常癫痫患者miR-130b-3p、FGL2高于脑电图轻度异常患者(P<0.05),miR-7低于轻度异常患者(P<0.05);癫痫患者miR-130b-3p及FGL2与疾病严重程度、脑电图异常程度呈正相关(P<0.05),miR-7与疾病严重程度、脑电图异常程度呈负相关(P<0.05)。结论癫痫患者血液miR-130b-3p及FGL2表达上调,而miR-7下调,3项指标均与与癫痫患者疾病严重程度、脑电图异常程度存在相关关系。Objective To explore the relationship between abnormal electroencephalogram(EEG)of patients with epilepsy and the expression characteristics of miR-130b-3p,miR-7 and fibrinogen-like-protein 2(FGL2).Methods A total of 124 epilepsy patients treated in our hospital were selected as the observation group,including 36 mild cases,51 moderate cases,and 37 severe cases.All the patients suffered from abnormal degree of EEG(65 mild cases,35 moderate cases,and 24 severe cases).The differences in miR-130b-3p,miR-7 and FGL2 of different kinds of subjects were compared.Results The miR-130b-3p and FGL2 levels in the observation group were significantly higher than those in the control group(P<0.05),and miR-7 was significantly lower than the control group(P<0.05).The miR-130b-3p and FGL2 levels in severe cases of the observation group were significantly higher than those in mild and moderate cases(P<0.05),and miR-7 was significantly lower than mild and moderate cases(P<0.05).The miR-130b-3p and FGL2 levels in cases with generalized seizures were significantly higher than those in cases with partial seizures(P<0.05).The miR-130b-3p and FGL2 levels in cases with severe EEG abnormalities in the observation group were significantly higher than those in patients with mild and moderate EEG abnormalities(P<0.05),and miR-7 was significantly lower than cases with mild and moderate abnormalities(P<0.05).The miR-130b-3p in the observation group was positively correlated with the severity of the disease and the degree of abnormal EEG(P<0.05).FGL2 in the observation group was positively correlated with the severity of the disease and the degree of abnormal EEG(P<0.05).There was a negative correlation(P<0.05)between miR-7 in the observation group and the severity of the disease and the degree of abnormal EEG.Conclusion The miR-130b-3p and FGL2 expression is upregulated,and miR-7 is down regulated in patients with epilepsy,which is correlated with the severity of the disease and the degree of electroencephalogram abnormalities.

关 键 词：癫痫 脑电图 miR-130b-3p miR-7 纤维蛋白原样蛋白2 严重程度 

分 类 号：R741[医药卫生—神经病学与精神病学]