蛋白质糖基化修饰在胰腺癌转移中的作用  

The Role of Protein Glycosylation in Metastasis of Pancreatic Cancer

作　　者：韦倩 陈家思 吕浩[1,2] 唐景峰[1,2] WEI Qian;CHEN Jiasi;LYU Hao;TANG Jingfeng(“111”Introduction Base of Cell Regulation and Molecular Medicine,Ministry of Science and Technology/Ministry of Education,Hubei University of Technology,Wuhan 430068,China;Key Laboratory of Fermentation Engineering,Ministry of Education,Hubei University of Technology,Wuhan 430068,China)

机构地区：[1]湖北工业大学科技部/教育部细胞调控与分子药物学科“111”引智基地,武汉430068 [2]湖北工业大学发酵工程教育部重点实验室,武汉430068

出　　处：《中国细胞生物学学报》2024年第6期1220-1228,共9页Chinese Journal of Cell Biology

基　　金：国家自然科学基金(批准号:82273970、82304561)资助的课题。

摘　　要：胰腺导管腺癌(pancreatic ductal adenocarcinoma,PDAC)是消化道常见的恶性肿瘤,因其早期没有明显的症状,而确诊时多已处于后期,并且很快转移,导致其难以治愈,死亡率极高。糖基化修饰是蛋白质翻译后的一种重要修饰,最常见的类型为O-糖基化和N-糖基化。在胰腺癌的发展过程中,蛋白质糖基化修饰发挥重要作用,尤其是在胰腺癌转移过程中发挥重要作用。异常的糖基化修饰可改变上皮–间充质转化和肿瘤微环境从而促进胰腺癌的转移进程。因此,研究糖基化修饰在胰腺癌细胞转移中的作用具有重要意义。该文就糖基化的基本结构及其在胰腺癌转移中的调节作用进行简要综述。PDAC(pancreatic ductal adenocarcinoma)is a common malignant tumor of the digestive system.Because it lacks clear symptoms in the early stages and is typically detected in the late and metastatic stages,it is difficult to cure and has a high death rate.Glycosylation is an important post-translational modification of proteins.The most common types are O-glycosylation and N-glycosylation.The protein glycosylation is closely related to the tumorigenesis of pancreatic cancer,especially plays a key role in the process of pancreatic cancer metastasis.Abnormal glycosylation modification can promote the metastasis of pancreatic cancer by changing epithelialmesenchymal transition and tumor microenvironment.Therefore,it is of great significance to elucidate the role of glycosylation modification in the metastasis of pancreatic cancer cells.This article reviews the basic structure of glycosylation and its regulatory role in pancreatic cancer metastasis.

关 键 词：糖基化 胰腺癌 癌症转移 治疗策略 

分 类 号：R735.9[医药卫生—肿瘤]