Unraveling the metabolic potential of biocontrol fungi through omics data:a key to enhancing large-scale application strategies  

作　　者：Haolin Yang Xiuyun Wu Caiyun Sun Lushan Wang 

机构地区：[1]State Key Laboratory of Microbial Technology,Institute of Microbial Technology,Shandong University,Qingdao 266237,China

出　　处：《Acta Biochimica et Biophysica Sinica》2024年第6期825-832,共8页生物化学与生物物理学报（英文版）

基　　金：supported by the the grants from Key Research and Development Program of Shandong Province(No.2021CXGC010803);the National Key Research and Development Program of China(No.2023YFC3403601).

摘　　要：Biological control of pests and pathogens has attracted much attention due to its green,safe and effective characteristics.However,it faces the dilemma of insignificant effects in large-scale applications.Therefore,an in-depth exploration of the metabolic potential of biocontrol fungi based on big omics data is crucial for a comprehensive and systematic understanding of the specific modes of action operated by various biocontrol fungi.This article analyzes the preferences for extracellular carbon and nitrogen source degradation,secondary metabolites(nonribosomal peptides,polyketide synthases)and their product characteristics and the conversion relationship between extracellular primary metabolism and intracellular secondary metabolism for eight different filamentous fungi with characteristics appropriate for the biological control of bacterial pathogens and phytopathogenic nematodes.Further clarification is provided that Paecilomyces lilacinus,encoding a large number of hydrolase enzymes capable of degrading pathogen protection barrier,can be directly applied in the field as a predatory biocontrol fungus,whereas Trichoderma,as an antibiosis-active biocontrol control fungus,can form dominant strains on preferred substrates and produce a large number of secondary metabolites to achieve antibacterial effects.By clarifying the levels of biological control achievable by different biocontrol fungi,we provide a theoretical foundation for their application to cropping habitats.

关 键 词：OMICS biocontrol fungi nonribosomal peptides(NRPs) polyketide synthase(PKS) metabolic transformation 

分 类 号：Q55[生物学—生物化学]