Single transmembrane GPCR modulating proteins:neither single nor simple  

作　　者：Meng Wang Jianjun Lyu Chao Zhang 

机构地区：[1]Department of Plastic and Reconstructive Surgery,Shanghai Ninth People’s Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200011,China [2]Hubei Topgene Research Institute of Hubei Topgene Biotechnology Co.,Ltd,East Lake High-Tech Development Zone,Wuhan 430205,China [3]Fundamental Research Center,Shanghai Yangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center),Tongji University,Shanghai 200092,China

出　　处：《Protein & Cell》2024年第6期395-402,共8页蛋白质与细胞（英文版）

基　　金：supported by the National Natural Science Foundation of China(Grant No.32271165);Shanghai Clinical Research Center of Plastic and Reconstructive Surgery supported by the Science and Technology Commission of Shanghai Municipality(Grant No.22MC1940300);the Innovative Research Team of High-level Local Universities in Shanghai(Grant No.SHSMU-ZDCX20210400);the Key Laboratory Program of the Education Commission of Shanghai Municipality(No.ZDSYS14005);China Postdoctoral Science Foundation(Grant No.2022M722127).

摘　　要：The discovery of G-protein coupled receptor(GPCR)accessory proteins has fundamentally redefined the pharmacological concept of GPCR signaling,demonstrating a more complex molecular basis for receptor specificity on the plasma membrane and impressionable downstream intracellular cascades.GPCR accessory proteins not only contribute to the proper folding and trafficking of receptors but also exhibit selectable receptor preferences.

关 键 词：specificity GPCR NEITHER 

分 类 号：Q26[生物学—细胞生物学]