Ferroptosis:a critical mechanism of N^(6)-methyladenosine modification involved in carcinogenesis and tumor progression  

作　　者：Qingqing Wei Changning Xue Mengna Li Jianxia Wei Lemei Zheng Shipeng Chen Yumei Duan Hongyu Deng Faqing Tang Wei Xiong Ming Zhou 

机构地区：[1]NHC Key Laboratory of Carcinogenesis,Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine,Central South University,Changsha 410013,China [2]Cancer Research Institute and School of Basic Medical Sciences,Central South University,Changsha 410078,China [3]The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education,Central South University,Changsha 410078,China [4]Hunan Key Laboratory of Oncotarget Gene,Hunan Key Laboratory of Cancer Metabolism,Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine,Central South University,Changsha 410013,China

出　　处：《Science China(Life Sciences)》2024年第6期1119-1132,共14页中国科学（生命科学英文版）

基　　金：supported by the National Natural Science Foundation of China(82172592);the Free Exploration Program of Central South University(2021zzts0934);the program of Introducing Talents of Discipline to Universities(111-2-12)。

摘　　要：Ferroptosis is an iron-dependent regulatory cell necrosis induced by iron overload and lipid peroxidation.It occurs when multiple redoxactive enzymes are ectopically expressed or show abnormal function.Hence,the precise regulation of ferroptosis-related molecules is mediated across multiple levels,including transcriptional,posttranscriptional,translational,and epigenetic levels.N^(6)-methyladenosine(m^(6)A)is a highly evolutionarily conserved epigenetic modification in mammals.The m^(6)A modification is commonly linked to tumor proliferation,progression,and therapy resistance because it is involved in RNA metabolic processes.Intriguingly,accumulating evidence suggests that dysregulated ferroptosis caused by the m^(6)A modification drives tumor development.In this review,we summarized the roles of m^(6)A regulators in ferroptosis-mediated malignant tumor progression and outlined the m^(6)A regulatory mechanism involved in ferroptosis pathways.We also analyzed the potential value and application strategies of targeting m^(6)A/ferroptosis pathway in the clinical diagnosis and therapy of tumors.

关 键 词：ferroptosis m6A modification RNA methylation m^(6)A regulator tumor progression 

分 类 号：R730[医药卫生—肿瘤]