Landscape of global urban environmental resistome and its association with local socioeconomic and medical status  

作　　者：Jun Wu Yige Hu Michael H Perlin David Danko Jun Lu Manuela Oliveira Johannes Werner Maria M Zambrano Maria A Sierra Olayinka O Osuolale Paweł Łabaj Nicolás Rascovan Nur Hazlin Hazrin-Chong Soojin Jang Haruo Suzuki Marina Nieto-Caballero Bharath Prithiviraj Patrick K H Lee Agnieszka Chmielarczyk Anna Różańska Yongxiang Zhao Lan Wang Christopher E Mason Tieliu Shi 

机构地区：[1]Center for Bioinformatics and Computational Biology,and the Institute of Biomedical Sciences,School of Life Sciences,East China Normal University,Shanghai 200241,China [2]Department of Biology,Program on Disease Evolution,University of Louisville,Louisville 40292,USA [3]Weill Cornell Medicine,New York 10065,USA [4]The Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine,New York 10065,USA [5]Department of Pulmonary Medicine,Shanghai Chest Hospital,Shanghai Jiao Tong University,Shanghai 200025,China [6]i3S-Instituto de Investiga玢o e Inova玢o em Saúde,Universidade do Porto,Porto 4050-290,Portugal [7]Ipatimup-Instituto de Patologia e Imunologia Molecular da Universidade do Porto,Porto 4200-465,Portugal [8]Departamento de Biologia,Faculdade de Ciências,Universidade do Porto,Porto 4050-290,Portugal [9]High Performance and Cloud Computing Group,Zentrum für Datenverarbeitung(ZDV),Eberhard Karls University of Tübingen,W鋍hterstra遝76,72074,Tübingen,Germany [10]Corporación Corpogen Research Center,Bogotá110311,Colombia [11]Applied Environmental Metagenomics and Infectious Diseases Research(AEMIDR),Department of Biological Sciences,Elizade University,Ilara-Mokin 340271,Nigeria [12]Maopolska Centre of Biotechnology,Jagiellonian University,Kraków 30-005,Poland [13]Aix-Marseille Université,Mediterranean Institute of Oceanology,Universitéde Toulon,CNRS,IRD,UM 110,Marseille 83041,France [14]Department of Biological Sciences and Biotechnology,Faculty of Science and Technology,Universiti Kebangsaan Malaysia,43600 UKM Bangi,Selangor [15]Institut Pasteur Korea,Seoul 13488,Republic of Korea [16]Faculty of Environment and Information Studies,Keio University,Fujisawa,Kanagawa 252-0882,Japan [17]University of Colorado at Boulder,Civil,Environmental and Architectural Department,Boulder 80303,USA [18]Brooklyn College of the City University of New York,Brooklyn 11210,USA [19]School of Energy and Environment,City University of Hong Kong,Hong Kong 999077,China [20]Department of Microbiology,Faculty of Med

出　　处：《Science China(Life Sciences)》2024年第6期1292-1301,共10页中国科学（生命科学英文版）

基　　金：supported by the National Key Research and Development Program of China(2023YFC2706503);the National Natural Science Foundation of China(32370720);Beihang University&Capital Medical University Plan(BHME-201904);the Open Research Fund of Key Laboratory of Advanced Theory and Application in Statistics and Data Science-MOE,ECNU,Key Laboratory of MEA,Ministry of Education,ECNU,Key Laboratory of Ecology and Energy Saving Study of Dense Habitat(Tongji University),Ministry of Education-Shanghai Tongji Urban Planning&Design Institute Co.,Ltd Joint Research Project(KY-2022-LH-A03);Shanghai Tongji Urban Planning&Design Institute Co.,Ltd-China Intelligent Urbanization Co-creation Center for High Density Region Research Project(KY-2022-PT-A02);the Irma T.Hirschl and Monique Weill-Caulier Charitable Trusts;Bert L and N Kuggie Vallee Foundation;the World Quant Foundation;The Pershing Square Sohn Cancer Research Alliance;the National Institutes of Health(R01AI151059);the National Science Foundation(1840275);the Alfred P.Sloan Foundation(G-2015-13964)。

摘　　要：Antimicrobial resistance(AMR)poses a critical threat to global health and development,with environmental factors—particularly in urban areas—contributing significantly to the spread of antibiotic resistance genes(ARGs).However,most research to date has been conducted at a local level,leaving significant gaps in our understanding of the global status of antibiotic resistance in urban environments.To address this issue,we thoroughly analyzed a total of 86,213 ARGs detected within 4,728 metagenome samples,which were collected by the Meta SUB International Consortium involving diverse urban environments in 60 cities of 27 countries,utilizing a deep-learning based methodology.Our findings demonstrated the strong geographical specificity of urban environmental resistome,and their correlation with various local socioeconomic and medical conditions.We also identified distinctive evolutionary patterns of ARG-related biosynthetic gene clusters(BGCs)across different countries,and discovered that the urban environment represents a rich source of novel antibiotics.Our study provides a comprehensive overview of the global urban environmental resistome,and fills a significant gap in our knowledge of large-scale urban antibiotic resistome analysis.

关 键 词：urban environment METAGENOME antibiotic resistance resistance diversity biosynthetic gene clusters 

分 类 号：R195[医药卫生—卫生统计学]