Rational design of a single-component mRNA vaccine against orthopoxvirus and SARS-CoV-2  

作　　者：Yilong Yang Xiaofan Zhao Yu Li Xiaodong Zai Xinyi Wang Yue Zhang Xiaolin Wang Peng Lv Jun Zhang Lihua Hou Junjie Xu Wei Chen 

机构地区：[1]Laboratory of Advanced Biotechnology,Beijing Institute of Biotechnology,Academy of Military Medical Sciences,Beijing 100071,China

出　　处：《Science China(Life Sciences)》2024年第6期1311-1313,共3页中国科学（生命科学英文版）

基　　金：supported in part by Beijing Nova Program of Science and Technology(20220484127);National Natural Science Foundation of China(82171818)。

摘　　要：Dear Editor,In the era of COVID-19,the prevalence of viruses from other families poses new threats to humans.Despite the eradication of smallpox in 1980,the global outbreak of monkeypox in 2022(Lum et al.,2022;Nuzzo et al.,2022)alerted that the re-emerging orthopoxvirus(OPXV)remained a persistent threat to global health.OPXV includes a number of viruses with a broad host range,including variola virus(VARV),monkeypox virus(MPXV),vaccinia virus(VACV).

关 键 词：VACCINE RATIONAL 

分 类 号：R392[医药卫生—免疫学]