中性淋巴比与中国汉族海洛因依赖人群的关系研究  

Neutrophil-lymphocyte ratio as an inflammatory biomarker in heroin dependence of Chinese Han

作　　者：张伟[1] 向明亮 王廷宏 邓小冬[1] 杨明[2] 刘云[1] ZHANG Wei;XIANG Ming-liang;WANG Ting-hong;DENG Xiao-dong;YANG Ming;LIU Yun(Department of Forensic Pathology,School of Basic Medicine and Forensic Medicine,North Sichuan Medical College,Nanchong 637000,Sichuan,China;Department of Criminal Investigation,Nanchong Public Security Bureau,Nanchong 637000,Sichuan,China)

机构地区：[1]川北医学院基础医学与法医学院法医病理教研室,四川南充637000 [2]南充市公安局物证鉴定所,四川南充637000

出　　处：《中国药物依赖性杂志》2024年第3期228-233,共6页Chinese Journal of Drug Dependence

基　　金：四川省基层卫生事业发展研究中心项目(SWFZ19-Q-05)。

摘　　要：目的中性淋巴比(neutrophil to lymphocyte ratios,NLR)、血小板淋巴比(platelet to lymphocyte ratios,PLR)和单核淋巴比(monocyte to lymphocyte ratios,MLR)是预测多种疾病炎症状态的敏感指标。本文主要探讨NLR、PLR和MLR对中国汉族海洛因依赖人群炎症水平的预测价值,并分析其与吸毒史相关指标之间的相关性。方法336例中国汉族海洛因依赖者(试验组)和325例健康人群(对照组)纳入研究,收集试验组和对照组人口学特征、吸毒史、血液学指标。计算并比较试验组和对照组NLR、PLR和MLR的差异。采用SPSS 13.0进行统计分析。结果试验组白细胞数(white blood cell,WBC)、中性粒细胞数(neutrophil,NEU)及其百分比、单核细胞数(monocyte,MO)及其百分比、NLR、PLR、MLR均显著高于对照组(P<0.001),试验组淋巴细胞(lymphocyte,LY)百分比低于对照组(P<0.001)。LY和血小板数(platelet,PLT)在两组间无统计学差异(P>0.05)。多因素分析显示NLR、PLR、NEU、MO是海洛因依赖的风险因素。ROC曲线分析显示NLR(AUC=0.86)、NEU(AUC=0.91)是预测海洛因依赖炎症水平的敏感指标(P<0.001)。相关性分析显示NLR与开始吸毒年龄、戒断症状发生率呈正相关(P<0.05),而与吸毒年限、吸毒量、吸毒频率、精神依赖和躯体依赖等吸毒特征无相关性(P>0.05)。NEU与上述吸毒指标均无相关性(P>0.05)。结论NLR是预测海洛因依赖炎症状态的敏感指标,并与开始吸毒年龄和戒断症状发生率相关。Objective Neutrophil to lymphocyte ratios(NLR),platelet to lymphocyte ratios(PLR),and monocyte to lymphocyte ratios(MLR)had emerged as useful inflammatory biomarkers in various diseases.The study aimed to explore the potential associations between NLR,PLR,MLR and heroin dependence,and explore their potential wider use in clinical research.Methods 336 heroin-dependent patients and 325 controls were enrolled.The demographics,history of heroin use,and hematologic parameters were compared.The NLR,PLR,and MLR were estimated and compared between the two groups.Results The count of white blood cell(WBC),neutrophil(NEU),monocyte(MO),NLR,MLR,and PLR were significantly higher,and the percentage of lymphocyte(LY)was significantly lower in heroin-dependent patients than controls(P<0.001).There was no difference in the LY and platelet(PLT)count between the two groups.Multivariate analysis showed that the NLR,PLR,MO,and NEU were identified as useful biomarkers to evaluate the inflammatory states of heroin dependence,respectively.However,there were no significant differences in WBC,LY,and MLR(P>0.05).Similar results were obtained after adjusting for age and gender.The receiver operating characteristic curve(ROC)analysis indicated that the NLR and NEU were useful parameters to identify the inflammatory states of heroin dependence(AUC:NLR=0.86,NEU=0.91,P<0.001).Furthermore,the NLR was significantly and positively associated with the begin age of drug use and withdrawal symptoms in heroin-dependent patients(P<0.05).However,the NEU was uncorrelated with those variables(P>0.05).Conclusions The NLR might serve as a useful clinical biomarker in inflammatory states of heroin dependence,and positively correlated with the begin age of drug use and withdrawal symptom of heroin dependence.

关 键 词：中性淋巴比 炎症指标 海洛因依赖 吸毒特征 

分 类 号：R749[医药卫生—神经病学与精神病学]