重复经颅磁刺激治疗抑郁症伴睡眠障碍的效果观察  

Effect of Repetitive Transcranial Magnetic Stimulation For Depression Complicated with Sleep Disorder

作　　者：陈巧云 孙美鸽 CHEN Qiaoyun;SUN Meige(Quanzhou Third Hospital 13th District,Quanzhou 362100,China)

机构地区：[1]泉州市第三医院,泉州362100

出　　处：《世界睡眠医学杂志》2024年第5期1095-1098,共4页World Journal of Sleep Medicine

摘　　要：目的:分析重复经颅磁刺激(rTMS)在合并睡眠障碍抑郁症患者治疗中的应用效果。方法:选取2022年4月至2023年12月泉州市第三医院收治的抑郁症合并睡眠障碍患者78例作为研究对象,按照随机数字表法分为对照组和观察组,每组39例。对照组采用药物治疗,观察组采用药物治疗+低频rTMS治疗。比较2组治疗后抑郁症状、睡眠质量与心率变异性。抑郁症状采用汉密顿抑郁量表(HAMD)评价,睡眠质量采用匹兹堡睡眠质量指数(PSQI)评价。结果:观察组在4周、8周后HAMD低于对照组,差异有统计学意义(P<0.05),PSQI与睡眠障碍发生率均显著较低,差异有统计学意义(P<0.05)。观察组4周后正常窦性心搏RR间期的标准差(SDNN)、24 h内每5 min RR间期平均值的标准差(SDANN)、总功率(TP)、高频(HF)、低频(LF)高于对照组,差异有统计学意义(P<0.05)。结论:低频rTMS可改善抑郁症合并睡眠障碍患者自主神经功能,减轻抑郁症状,减少睡眠障碍。Objective:To analyze the effect of rTMS in the treatment of depression complicated with sleep disorder.Methods:A total of 78 patients with depression combined with sleep disorder were divided into observation group(n=39)and control group(n=39)by random number table method.The control group received drug treatment,while the observation group received drug treatment+low-frequency rTMS therapy.The depression symptoms,sleep quality,and heart rate variability were compared after treatment.Depression was evaluated using the HAMD-24,and sleep quality was evaluated using PSQI.Results:Compared to the control group,HAMD score of observation group was significantly lower at 4 w and 8 w(P<0.05),and the PSQI and incidence of sleep disorder were significantly lower(P<0.05).SDNN,SDANN,TP,HF,and LF of observation group were higher than those of control group at 4 w(P<0.05).Conclusion:Low-frequency rTMS can improve autonomic nervous function in patients with depression complicated with sleep disorder,alleviate depressive symptoms,and reduce sleep disorders.

关 键 词：抑郁症 睡眠障碍 重复经颅磁刺激 汉密顿抑郁量表 心率变异性 

分 类 号：R749.4[医药卫生—神经病学与精神病学] R338.63[医药卫生—临床医学]