奥美拉唑联合白眉蛇毒血凝酶对消化性溃疡并出血患者凝血指标及血小板参数变化的影响  

Effects of omeprazole combined with hemagglutinase on coagulation index and platelet parameters in patients with peptic ulcer complicated with hemorrhage

作　　者：危伸 杨瑞荣 廖琴 WEI Shen;YANG Ruirong;LIAO Qin(Department of Gastroenterology,Ruijin City General Hospital/People's Hospital of Ruijin City,Ruijin,Jiangxi,342500,China)

机构地区：[1]瑞金市总医院/瑞金市人民医院消化内科,江西瑞金342500

出　　处：《当代医学》2024年第6期48-51,共4页Contemporary Medicine

摘　　要：目的探讨奥美拉唑联合白眉蛇毒血凝酶的治疗消化性溃疡并出血患者的临床疗效。方法选取2020年4月至2022年3月瑞金市总医院/瑞金市人民医院收治的80例消化性溃疡并出血患者作为研究对象,采用单双号法分为对照组与研究组,每组40例。对照组采用奥美拉唑治疗,研究组采用奥美拉唑联合白眉蛇毒血凝酶治疗,比较两组凝血功能指标、血小板参数、临床疗效、临床指标及不良反应发生情况。结果治疗后,两组凝血酶时间(TT)、凝血酶原时间(PT)及活化部分凝血活酶时间(APTT)均短于治疗前,且研究组短于对照组,差异有统计学意义(P<0.05)。治疗后,两组血小板计数(PLT)均高于治疗前,血小板比容(PCT)均大于治疗前,血小板体积(MPV)均小于治疗前,且研究组PLT高于对照组,PCT大于对照组,MPV小于对照组,差异有统计学意义(P<0.05)。研究组治疗总有效率为97.50%,高于对照组的77.50%,差异有统计学意义(P<0.05)。研究组止血时间、住院时间均短于对照组,复发率低于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较差异无统计学意义。结论奥美拉唑联合白眉蛇毒血凝酶治疗消化性溃疡并出血疗效更佳,可有效改善患者凝血指标及血小板参数,缩短止血时间、住院时间,降低复发率,且安全性较高。Objective To investigate the clinical efficacy of omeprazole combined with hemagglutinase in the treatment of patients with peptic ulcer complicated with hemorrhage.Methods 80 patients with peptic ulcer complicated with hemorrhage admitted to Ruijin City General Hospital/Ruijin People's Hospital from April 2020 to March 2022 were selected as the study subjects,and they were randomly divided into the control group and the study group by odd-even grouping method,with 40 cases in each group.The control group was treated with omeprazole,and the study group was treated with omeprazole combined with hemagglutinin,the coagulation function indexes,platelet parameters,clinical efficacy,clinical indexes and occurrence of adverse reactions were compared between the two groups.Results After treatment,thrombin time(TT),prothrombin time(PT)and activated partial thrombin time(APTT)of the two groups were shorter than before treatment,and the study group was shorter than the control group,the differences were statistically significant(P<0.05).After treatment,platelet count(PLT)of the two groups were higher than before treatment,platelet specific volume(PCT)was larger than before treatment,platelet volume(MPV)was smaller than before treatment,and PLT in the study group was higher than that in the control group,PCT was arger than that in the control group,MPV was smaller than that in the control group,the differences were statistically significant(P<0.05).The total effective rate in the study group was 97.50%,which was higher than 77.50%in the the control group,and the difference was statistically significant(P<0.05).The hemostasis time and hospitalization time in the study group were shorter than those in the control group,and the recurrence rate was lower than that in the control group,the differences were statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups.Conclusion Omeprazole combined with hemagglutinin is more effective in the treatment of pe

关 键 词：消化性溃疡出血 奥美拉唑 白眉蛇毒血凝酶 凝血指标 血小板参数 

分 类 号：R573.1[医药卫生—消化系统]