血管内介入联合静脉溶栓治疗对老年急性缺血性脑血管病患者脑血管血流状态与凝血功能及神经功能的影响  

Effects of intravascular intervention combined with intravenous thrombolysis on cerebrovascular blood flow status and coagulation function and neurological function in elderly patients with acute ischemic cerebrovascular disease

作　　者：高海玲 GAO Hailing(Second Department of Neurology,Linqing people's Hospital,Liaocheng,Shandong,252600,China)

机构地区：[1]临清市人民医院神经内二科,山东聊城252600

出　　处：《当代医学》2024年第6期114-117,共4页Contemporary Medicine

摘　　要：目的探讨血管内介入联合静脉溶栓治疗对老年急性缺血性脑血管病患者脑血管血流状态与凝血功能及神经功能的影响。方法选取2020年11月至2021年11月临清市人民医院收治的86例老年急性缺血性脑血管病患者作为研究对象,其中2020年11月至2021年4月收治的患者作为参照组,2021年5—11月收治的患者作为联合组,每组43例。参照组给予静脉溶栓治疗,联合组给予血管内介入联合静脉溶栓治疗。比较两组脑血管血流状态[舒张期最小血流速度(Vdmin)、收缩期最大血流速度(Vsmax)及平均血流速度(Vm)]、凝血功能[活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)、D-二聚体(D-D)及纤维蛋白原(Fg)]、神经功能[美国国立卫生研究院卒中量表(NIHSS)]及血管再通率。结果治疗后,两组Vdmin、Vsmax、Vm均快于治疗前,且联合组快于参照组,差异有统计学意义(P<0.05)。治疗后,两组APTT、PT均长于治疗前,且D-D、Fg水平均低于治疗前,差异有统计学意义(P<0.05),但两组组间比较差异无统计学意义。治疗12、24h后,两组NIHSS评分均低于前一时间点,且联合组低于参照组,差异有统计学意义(P<0.05)。联合组血管再通率为81.40%,高于参照组的60.47%,差异有统计学意义(P<0.05)。结论血管内介入联合静脉溶栓治疗老年急性缺血性脑血管病患者疗效确切,能明显改善患者脑部血管血流状态、神经功能,提高血管再通率,且不影响患者凝血功能指标,值得临床推广与应用。Objective To investigate the effects of intravascular intervention combined with intravenous thrombolysis on cerebrovascular blood flow status and coagulation function and nerve function in elderly patients with acute ischemic cerebrovascular disease.Methods A total of 86 elder-ly patients with acute ischemic cerebrovascular disease admitted to Linqing People's Hospital from November 2020 to November 2021 were selected as the study subjects,patients admitted from November 2020 to April 2021 as the reference group,and patients admitted from May to November 2021 as the combination group,with 43 cases in each group.The reference group was given intravenous thrombolytic therapy,and the combination group was given intravascular intervention combined with intravenous thrombolytic therapy.The cerebral blood flow status(minimum diastolic blood flow velocity[Vdmin],maximum systolic blood flow velocity[Vsmax]and average blood flow velocity[Vm]),coagulation function(activat-ed partial thromboplastin time[APTT],prothrombin time[PT],D-dimer[D-D]and fibrinogen[Fg])and neurological function(National Institute of Health stroke scale[NIHSS]),and vascular revascularization rate were compared between the two groups.Results After treatment,Vdmin,Vsmax and Vm of the two groups were faster than before treatment,and the combination group was faster than the reference group,and the differences were statistically significant(P<0.05).After treatment,APTT and PT of the two groups were longer than before treatment,and D-D and Fg levels were lower than those before treatment,and the differences were statistically significant(P<0.05),but there was no significant difference between the two groups.After 12 and 24 h of treatment,the NIHSS scores of the two groups were lower than the previous time point,and the combination group was lower than the reference group,the differences were statistically significant(P<0.05).The vascular revascularization rate in the combined group was 81.40%,which was higher than 60.47%in the reference group,and the dif

关 键 词：血管内介入 静脉溶栓 老年 急性缺血性脑血管病 神经功能 凝血功能 脑血管血流 

分 类 号：R743.3[医药卫生—神经病学与精神病学]