银杏酮酯分散片用于脑梗死二级预防对颈动脉斑块面积、血液流变学及炎症水平的影响  

Effects of ginkgo ketone ester dispersible tablets on carotid plaque area,hemorheology and inflammation level in secondary prevention of cerebral infarction

作　　者：狄美琪 殷晓菁 桂树华 李超生 韩利坤 胡玲玲 DI Mei-qi;YIN Xiao-jing;GUI Shu-hua(Department of Neurology,Affiliated Hospital of Jiangnan University,Wuxi 214000,China)

机构地区：[1]江南大学附属医院神经内科,214000

出　　处：《中国实用医药》2024年第13期1-5,共5页China Practical Medicine

摘　　要：目的 观察银杏酮酯分散片(商品名:银欣可)用于脑梗死二级预防对颈动脉斑块面积、血液流变学及炎症水平的影响。方法 选取80例急性脑梗死患者为研究对象,采用单双数标记法分为西药组(37例)和银欣可组(43例)。研究过程中西药组失访1例,银欣可组失访2例,最终西药组36例、银欣可组41例。西药组患者口服阿司匹林或氯吡格雷,均联合阿托伐他汀治疗,银欣可组患者在西药组基础上联合银欣可治疗。比较两组治疗前和治疗6个月后血液流变学[全血低切粘度、全血高切粘度、血浆粘度、红细胞沉降率(ESR)、纤维蛋白原(FIB)、血小板聚集率]、颈动脉斑块情况[颈动脉斑块面积、颈动脉内中膜厚度(IMT)、颈动脉狭窄率]、胱抑素C(Cys-C)、视黄醇结合蛋白(RBP)、超敏C反应蛋白(hs-CRP)差异,随访1年内临床事件发生情况。结果 与治疗前比,两组治疗后全血低切粘度、全血高切粘度、血浆粘度、ESR、FIB、血小板聚集率下降,且银欣可组均低于西药组(P<0.05)。与治疗前比,两组治疗后IMT、颈动脉斑块面积、颈动脉狭窄率下降,且银欣可组IMT(0.87±0.10)mm、颈动脉斑块面积(11.14±1.56)mm^(2)、颈动脉狭窄率(31.56±4.23)%低于西药组的(0.93±0.15)mm、(13.44±2.02)mm^(2)、(36.85±5.02)%(P<0.05)。与治疗前比,两组治疗后hs-CRP、RBP、Cys-C下降,且银欣可组hs-CRP(7.78±2.15)mg/L、RBP(41.32±6.77)mg/L、Cys-C(0.95±0.21)mg/L低于西药组的(10.14±2.74)、(50.26±8.17)、(1.12±0.38)mg/L(P<0.05)。银欣可组随访1年内脑梗死复发率为4.88%(2/41),低于西药组的22.22%(8/36)(P<0.05)。两组随访1年内症状性消化道出血、脑出血、急性心肌梗死、心力衰竭、恶性心律失常、心源性死亡发生率比较,无统计学差异(P>0.05)。结论 银欣可用于脑梗死二级预防可缩小颈动脉斑块面积,减少脑梗死复发率,可能与改善血液流变学、抑制炎症反应有关。Objective To observe the effect of ginkgo ketone ester dispersible tablets(trade name:Yinxinke)on carotid plaque area,hemorheology and inflammation level in secondary prevention of cerebral infarction.Methods 80 patients with acute cerebral infarction were selected as the study subjects,and were divided into western medicine group(37 cases)and Yinxinke group(43 cases)by single and double number labeling method.During the study,1 case was lost to follow-up in the western medicine group,2 cases was lost to follow-up in the Yinxinke group,resulting in 36 cases in the western medicine group and 41 cases in the Yinxinke group.Patients in the western medicine group were treated with oral aspirin or clopidogrel combined with atorvastatin,while patients in the Yinxinke group were treated with ginkgo ketoester dispersible tablets on the basis of the western medicine group.Both groups were compared in terms of difference in hemorheology[whole blood low shear viscosity,whole blood high shear viscosity,plasma viscosity,erythrocyte sedimentation rate(ESR),fibrinogen(FIB),platelet aggregation rate],carotid plaque[carotid plaque area,carotid intima-media thickness(IMT),carotid artery stenosis rate],cystatin C(Cys-C),retinol binding protein(RBP),hypersensitive C-reactive protein(hs-CRP)before and after 6 months of treatment,and occurrence of clinical events within 1-year follow-up.Results Compared with before treatment,the whole blood low shear viscosity,whole blood high shear viscosity,plasma viscosity,ESR,FIB and platelet aggregation rate were decreased in both groups after treatment,and Yinxinke group was lower than western medicine group(P<0.05).Compared with before treatment,IMT,carotid plaque area and carotid stenosis rate decreased in both groups after treatment;Yinxinke group had IMT of 2(0.87±0.10)mm,carotid plaque area of(11.14±1.56)mm and carotid artery stenosis rate of(31.56±4.23)%,2 which were lower than(0.93±0.15)mm,(13.44±2.02)mm and(36.85±5.02)%in western medicine group(P<0.05).Compared with before treatmen

关 键 词：银杏酮酯分散片 脑梗死 二级预防 颈动脉斑块 复发 血液流变学 炎症 

分 类 号：R743.33[医药卫生—神经病学与精神病学]