老年胃溃疡患者经益生菌联合抗Hp方案治疗的可行性及对肠道菌群分布的影响研究  

Study on the feasibility of probiotics combined with anti-Hp regimen in the treatment of elderly patients with gastric ulcer and its influence on distribution of gut microbiota

作　　者：陈名 郭霞 CHEN Ming;GUO Xia(Department of Gastroenterology,Chongyi County People's Hospital,Ganzhou 341300,China)

机构地区：[1]江西省崇义县人民医院消化内科,341300

出　　处：《中国实用医药》2024年第13期112-114,共3页China Practical Medicine

摘　　要：目的 探究益生菌联合抗幽门螺杆菌(Hp)方案治疗老年胃溃疡患者的可行性及对肠道菌群分布的影响。方法 60例老年胃溃疡患者,采用计算机随机分组为观察组和对照组,每组30例。观察组患者经益生菌联合抗Hp方案治疗,对照组患者应用抗Hp方案治疗。比较两组患者的肠道菌群分布、不良反应发生率和复发率。结果 治疗前,两组患者肠杆菌、酵母菌以及双歧杆菌比较,差异无统计学意义(P>0.05);观察组患者治疗14 d后肠杆菌(7.98±0.12)lgCFU/g、酵母菌(8.86±0.38)lgCFU/g、双歧杆菌(8.24±0.38)lgCFU/g均高于对照组的(7.65±0.16)、(8.52±0.29)、(7.68±0.42)lgCFU/g,差异有统计学意义(P<0.05)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。观察组复发率为3.33%,低于对照组的20.00%,差异有统计学意义(P<0.05)。结论 改善老年胃溃疡患者的干预方式时,选择经益生菌联合抗Hp方案治疗具有明显疗效,有助于改善患者的肠道菌群,减少溃疡复发。Objective To explore the feasibility of probiotics combined with anti-Helicobacter pylori(Hp)regimen in the treatment of elderly patients with gastric ulcer and its influence on distribution of gut microbiota.Methods 60 elderly patients with gastric ulcers were divided into the observation group and the control group according to computer random grouping method,with 30 cases in each group.Patients in the observation group were treated with probiotics combined with anti-Hp regimen,while patients in the control group were treated with anti-Hp regimen.The distribution of gut microbiota,incidence of adverse reactions,and recurrence rates were compared between the two groups of patients.Results Before treatment,there was no significant difference in enterobacteriaceae,yeast and bifidobacterium between the two groups(P>0.05).After 14 d of treatment,the observation group had enterobacteriaceae of(7.98±0.12)lgCFU/g,yeast of(8.86±0.38)lgCFU/g,bifidobacterium of(8.24±0.38)lgCFU/g,which were higher than(7.65±0.16),(8.52±0.29)and(7.68±0.42)lgCFU/g in the control group,and the difference was statistically significant(P<0.05).When comparing the incidence of adverse reactions,it was found that there was no significant difference in data between the two groups(P>0.05).The recurrence rate of the observation group was 3.33%,which was lower than 20.00%of the control group,and the difference was statistically significant(P<0.05).Conclusion When improving the intervention methods for elderly gastric ulcer patients,choosing a combination of probiotics and anti-Hp regimen has significant therapeutic effects,which helps to improve the patient's gut microbiota and reduce ulcer recurrence.

关 键 词：老年胃溃疡 抗幽门螺杆菌方案 益生菌 肠道菌群分布 

分 类 号：R573.1[医药卫生—消化系统]